3.5.4.38: single-stranded DNA cytosine deaminase

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For detailed information about single-stranded DNA cytosine deaminase, go to the full flat file.

Word Map on EC 3.5.4.38

3.5.4.38

apobec3s

deamination

hypermutation

deaminases

immunoglobulin

uracil

viruses

apolipoprotein

retroviruses

diversification

ige

virion

polypeptide-like

retroviral

mrna-editing

retrotransposons

antiretroviral

retroelements

vif-deficient

anti-hiv-1

retrotransposition

class-switching

glycosylase

lentiviruses

uracil-dna

line-1

proviral

vif-mediated

aid-dependent

cccdna

aid-induced

abasic

c-to-u

encapsidation

translesion

r-loops

sivmac

molecular biology

samhd1

medicine

Reaction

Synonyms

A3F, activation-induced cytidine deaminase, activation-induced deaminase, AICDA, AID, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC3H, APOBEC3Z1, CDA1, single-stranded (ss)DNA deoxycytidine deaminase, ssDNA cytidine deaminase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.38 single-stranded DNA cytosine deaminase

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Results	in table
1	Activating Compound
179	AA Sequence
2	Application
15	Cloned(Commentary)
8	Crystallization (Commentary)
1237	Disease/ Diagnostics
3	Expression
28	General Information
1	General Stability
4	Inhibitors
1	KM Value [mM]
8	Localization
2	Metals/Ions
9	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
61	Organism
35	PDB ID
11	pH Optimum
1	pH Range
8	Posttranslational Modification
29	Protein Variants
13	Purification (Commentary)
1	Reaction
47	Reference
30	Source Tissue
59	Substrates and Products (Substrate)
11	Subunits
93	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

KM Value

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KM Value on EC 3.5.4.38 - single-stranded DNA cytosine deaminase

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additional information

Homo sapiens

Q9GZX7

Km of glutathione S-transferase-AID for the hot-spot transcription bubble substrate HS1bub7 is between 10 and 15 nM. It is not possible to estimate the Km for the cold-spot bubble (i.e., CS1bub7) since the substrate saturation kinetics is not observed. However, as the velocity continues to increase beyond the highest substrate concentration tested, the Km is likely to be severalfold higher for CS1bub7 than for HS1bub7

688963