3.5.4.29: GTP cyclohydrolase IIa

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For detailed information about GTP cyclohydrolase IIa, go to the full flat file.

Reaction

Synonyms

GCH III, GTP cyclohydrolase III, MJ0145

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.29 GTP cyclohydrolase IIa

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Results	in table
1	Activating Compound
950	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Crystallization (Commentary)
14	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
10	Metals/Ions
4	Molecular Weight [Da]
3	Organism
5	Pathway
4	PDB ID
1	pH Optimum
1	Protein Variants
2	Purification (Commentary)
2	Reaction
2	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
7	Substrates and Products (Substrate)
5	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.5.4.29 - GTP cyclohydrolase IIa

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SYSTEMATIC NAME

IUBMB Comments

GTP 8,9-hydrolase (phosphate-forming)

Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate.