3.5.4.29: GTP cyclohydrolase IIa

This is an abbreviated version!
For detailed information about GTP cyclohydrolase IIa, go to the full flat file.

Reaction

+ 3 H2O =

2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

+ 2 phosphate

Synonyms

GCH III, GTP cyclohydrolase III, MJ0145

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.29 GTP cyclohydrolase IIa

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1	Activating Compound
950	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Crystallization (Commentary)
14	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
10	Metals/Ions
4	Molecular Weight [Da]
3	Organism
5	Pathway
4	PDB ID
1	pH Optimum
1	Protein Variants
2	Purification (Commentary)
2	Reaction
2	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
7	Substrates and Products (Substrate)
5	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.5.4.29 - GTP cyclohydrolase IIa

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beta,gamma-methylene-GTP + H2O

2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + methyl phosphonate

Methanocaldococcus jannaschii

Q57609

639020

dGTP + H2O

2-amino-5-formylamino-6-hydroxy-4-(deoxy-5-phosphoribosylamino)-pyrimidine + phosphate

Methanocaldococcus jannaschii

Q57609

639020

diphosphate + H2O

2 phosphate

Methanocaldococcus jannaschii

Q57609

639020

GTP + 3 H2O

2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate

2 entries

GTP + H2O

2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + phosphate

Methanocaldococcus jannaschii

Q57609

639020

enzyme has diphosphate phosphohydrolase and GTP cyclohydrolase activities, no activity with 8-bromo-GTP, 8-azido-GTP, alpha,beta-methylene-GTP, ATP, GDP, GMP and XTP

639020

GTP-gamma-S + H2O

2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + ?

Methanocaldococcus jannaschii

Q57609

639020