3.5.4.19: phosphoribosyl-AMP cyclohydrolase

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For detailed information about phosphoribosyl-AMP cyclohydrolase, go to the full flat file.

Word Map on EC 3.5.4.19

3.5.4.19

hi

vannielii

phosphoribosyl-atp

methanobacterium

methanococcus

metalloenzyme

purine

thermoautotrophicum

drug development

Reaction

1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide

Synonyms

HisI, N1-(5'-phosphoribosyl) adenosine-5'-monophosphate cyclohydrolase, phosphoribosyladenosine monophosphate cyclohydrolase, PR-AMP cyclohydrolase, PRA-CH, PRAMP-cyclohydrolase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.19 phosphoribosyl-AMP cyclohydrolase

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Results	in table
36161	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
3	General Information
5	Inhibitors
10	KM Value [mM]
5	Metals/Ions
6	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
8	Organism
6	Pathway
14	PDB ID
2	pH Optimum
1	pH Range
8	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
8	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
7	Substrates and Products (Substrate)
3	Subunits
10	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Turnover Number [1/s]

Purification

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Purification on EC 3.5.4.19 - phosphoribosyl-AMP cyclohydrolase

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3 entries

recombinant enzyme from Escherichia coli by anion exchange chromatography and dialysis

Methanothermobacter thermautotrophicus

667617