3.5.4.19: phosphoribosyl-AMP cyclohydrolase
This is an abbreviated version!
For detailed information about phosphoribosyl-AMP cyclohydrolase, go to the full flat file.
Word Map on EC 3.5.4.19
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3.5.4.19
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hi
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vannielii
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phosphoribosyl-atp
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methanobacterium
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methanococcus
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metalloenzyme
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purine
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thermoautotrophicum
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drug development
- 3.5.4.19
- hi
- vannielii
-
phosphoribosyl-atp
-
methanobacterium
-
methanococcus
-
metalloenzyme
- purine
- thermoautotrophicum
- drug development
Reaction
Synonyms
HisI, N1-(5'-phosphoribosyl) adenosine-5'-monophosphate cyclohydrolase, phosphoribosyladenosine monophosphate cyclohydrolase, PR-AMP cyclohydrolase, PRA-CH, PRAMP-cyclohydrolase
ECTree
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Engineering
Engineering on EC 3.5.4.19 - phosphoribosyl-AMP cyclohydrolase
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C109/C116
no measurable catalytic activity, not capable of binding Zn2+
C109A
no measurable catalytic activity, not capable of binding Zn2+
C116A
no measurable catalytic activity, still capable of binding Zn2+
D92E
180fold loss in catalytic efficiency (kcat/Km), decrease in Zn2+ content
D94A
no measurable catalytic activity, decrease in Zn2+ content
H110A
500fold decrease in activity, no decrease in Zn2+ content