3.5.4.19: phosphoribosyl-AMP cyclohydrolase

This is an abbreviated version!
For detailed information about phosphoribosyl-AMP cyclohydrolase, go to the full flat file.

Reaction

Synonyms

HisI, N1-(5'-phosphoribosyl) adenosine-5'-monophosphate cyclohydrolase, phosphoribosyladenosine monophosphate cyclohydrolase, PR-AMP cyclohydrolase, PRA-CH, PRAMP-cyclohydrolase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.19 phosphoribosyl-AMP cyclohydrolase

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Results	in table
36161	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
3	General Information
5	Inhibitors
10	KM Value [mM]
5	Metals/Ions
6	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
8	Organism
6	Pathway
14	PDB ID
2	pH Optimum
1	pH Range
8	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
8	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
7	Substrates and Products (Substrate)
3	Subunits
10	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.5.4.19 - phosphoribosyl-AMP cyclohydrolase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5,5'-dithiobis(2-nitrobenzoic acid)

Methanococcus vannielii

Q50837

compromises the Zn2+ binding properties of the protein inducing loss of up to 90% of the metal. The enzyme is protected from inactivation by inclusion of the substrate N1-(5'-phosphoribosyl)adenosine 5'-monophosphate, while Mg2+, a metal required for catalytic activity, enhanced the rate of inactivation

726992

EDTA

Methanococcus vannielii

-

reversible inhibition

246720

methyl methane thiosulfonate

Methanococcus vannielii

Q50837

compromises the Zn2+ binding properties of the protein inducing loss of up to 90% of the metal

726992

Zn2+

Methanococcus vannielii

-

exogenous Zn2+

246720

additional information

Brucella melitensis bv. 1

Q8YH95

ZINC04880153 can be considered as one of the potential lead molecule against HisI drug target in Brucella melitensis. Low binding energy (-9.1kcal/mol) with a molecular weight of 228.191 g/mol. It has 2 H-bond donors and 7 H-bond acceptors. The movement of ZINC04880153 in the binding pockets of HisI shows stability and compact structure with respect to the initial computational model of HisI

757253

-