3.5.1.69: glycosphingolipid deacylase
This is an abbreviated version!
For detailed information about glycosphingolipid deacylase, go to the full flat file.
Reaction
Synonyms
deacylase, glycosphingolipid ceramide, glycosphingolipid ceramide deacylase, PS_SCD, SA_SCD, SCDase, sphingolipid ceramide N-acylase, sphingolipid ceramide N-deacylase
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Metals Ions
Metals Ions on EC 3.5.1.69 - glycosphingolipid deacylase
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Ca2+
Co2+
Fe2+
promotes the hydrolytic activity but inhibits the synthetic activity of the enzyme
Mg2+
Mn2+
Ni2+
promotes the hydrolytic activity but inhibits the synthetic activity of the enzyme
additional information
Ca2+
promotes the hydrolytic activity but inhibits the synthetic activity of the enzyme
Ca2+
required, activtes. GM1 hydrolysis increases with increasing Ca 2+ concentration, compared with 40.7% yield in the absence of Ca2+, the addition of 100 mM Ca2+ enhances the yield to 81.6%. Best at 50-100 mM
promotes the hydrolytic activity but inhibits the synthetic activity of the enzyme
Co2+
activates, but slightly less effectve compared to Ca2+, at 100 mM
Mg2+
promotes the hydrolytic activity but inhibits the synthetic activity of the enzyme
Mn2+
promotes the hydrolytic activity but inhibits the synthetic activity of the enzyme