3.5.1.122: protein N-terminal glutamine amidohydrolase
This is an abbreviated version!
For detailed information about protein N-terminal glutamine amidohydrolase, go to the full flat file.
Reaction
Synonyms
C8orf32, Cg8253, CT1, FLJ10204, Gln-specific amino-terminal (Nt)-amidase, glutamine-specific N-terminal amidase, hNtaq1, human N-terminal glutamine amidohydrolase isoform 1, N-terminal amidase, Nt-amidase, NTA1, Ntaq, NTAQ1, NtQ-amidase, Wdyhv1, yNta1
ECTree
Advanced search results
Systematic Name
Systematic Name on EC 3.5.1.122 - protein N-terminal glutamine amidohydrolase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
protein N-terminal glutamine amidohydrolase
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.