3.4.24.B38: ammodytagin
This is an abbreviated version!
For detailed information about ammodytagin, go to the full flat file.
Reaction
The enzyme hydrolyzes bovine insulin B-chain at positions Gln4-/-His5, His10-/-Leu11 and Tyr16-/-Leu17. The enzyme possesses potent azocaseinolytic activity. =
ECTree
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Substrates Products on EC 3.4.24.B38 - ammodytagin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
bovine factor X + H2O
?
cleavage occurs at position Gln49-/-Cys50 in the light chain and at position Asp173-/-Leu174 in the heavy chain
-
-
?
bovine oxidized insulin B-chain + H2O
?
the enzyme hydrolyzes at positions Gln4His5, His10Leu11 and Tyr16Leu17. No other peptide bond hydrolysis is detected after 30 min of incubation
-
-
?
human fibrinogen alpha-chain + H2O
?
hydrolysis at multiple positions, including Ser220-/-Gln221, Lys413-/-Leu414, Glu422-/-Leu423 and Glu520-/-Phe521. Hydrolysis at lower rate (after 6 h) is detected at sites Asn109-/-Arg110, Arg23-/-Met240 and Arg491-/-His492
-
-
?
human fibrinogen beta-chain + H2O
?
the fibrinogen beta-chain is cleaved much slower than the alpha-chain
-
-
?
Nidogen + H2O
?
in Matrigel Growth Factor Reduced, nidogen is cleaved at positions Val422-/-Phe423 and Tyr352-/-Asn353
-
-
?
additional information
?
-
the enzyme acts as a strong hemorrhagin in both rats and mice. Laminin is not cleaved even after 24 h treatment with ammodytagin. No cleavage of the human fibrinogen gamma-chain
-
-
?
additional information
?
-
-
the enzyme acts as a strong hemorrhagin in both rats and mice. Laminin is not cleaved even after 24 h treatment with ammodytagin. No cleavage of the human fibrinogen gamma-chain
-
-
?
