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3.4.24.29: aureolysin

This is an abbreviated version!
For detailed information about aureolysin, go to the full flat file.

Word Map on EC 3.4.24.29

Reaction

Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus =

Synonyms

Aur, aurWM, C3 convertase, EC 3.4.24.4, EC 3.4.99.22, Proteinase, Staphylococcus aureus neutral, Staphylococcus aureus neutral protease, Staphylococcus aureus neutral proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.29 aureolysin

Inhibitors

Inhibitors on EC 3.4.24.29 - aureolysin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
Ag2+
-
protease II
alpha2-Macroglobulin
-
a regulatory serpin, the initial N-terminal hydrolysis of alpha2-macroglobulin by aureolysin does not affect the serpin inhibitory activity, cleavage within its exposed reactive loop is associated with a decreased inhibitory activity, down to 23% of the control inhibitor
-
Co2+
-
protease II inactive in presence of, protease I slightly stimulated
Cu2+
-
protease II
DFP
-
1.0 mM, 30 min, 20°C, activity of protease I is reduced by 10%, activity of protease II by 30%
Hg2+
-
protease II
Mn2+
-
protease II
NaCl
-
50% reduction of activity at 0.3 M for protease I and 0.5 M for protease II
plasminogen activator inhibitor-1
-
PAI-1, a regulatory serpin, interaction analysis with aureolysin, overview, the proteolytic degradation of PAI-1 by aureolysin is associated with a drastic decrease in its capacity to inhibit uPA, down to 7% of the inhibitory activity of the control PAI-1
Zn2+
-
protease II
additional information
-