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3.4.24.29: aureolysin

This is an abbreviated version!
For detailed information about aureolysin, go to the full flat file.

Word Map on EC 3.4.24.29

Reaction

Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus =

Synonyms

Aur, aurWM, C3 convertase, EC 3.4.24.4, EC 3.4.99.22, Proteinase, Staphylococcus aureus neutral, Staphylococcus aureus neutral protease, Staphylococcus aureus neutral proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.29 aureolysin

Reference

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Reference on EC 3.4.24.29 - aureolysin

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arvidson, S.; Holme, T.; Lindholm, B.
Studies on extracellular proteolytic enzymes from Staphylococcus aureus. I. Purification and characterization of one neutral and one alkaline protease
Biochim. Biophys. Acta
302
135-148
1973
Staphylococcus aureus, Staphylococcus aureus V8
Manually annotated by BRENDA team
Drapeau, G.R.
Role of metalloprotease in activation of the precursor of staphylococcal protease
J. Bacteriol.
136
607-613
1978
Staphylococcus aureus
Manually annotated by BRENDA team
Potempa, J.; Porwit-Bobr, Z.; Travis, J.
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase
Biochim. Biophys. Acta
993
301-304
1989
Staphylococcus aureus
Manually annotated by BRENDA team
Saheb, S.A.
Purification and properties of a metalloprotease from Staphylococcus aureus
Biochimie
60
429-435
1978
Staphylococcus aureus, Staphylococcus aureus A152
Manually annotated by BRENDA team
Banbula, A.; Potempa, J.; Travis, J.; Fernandez-Catalan, C.; Mann, K.; Huber, R.; Bode, W.; Medrano, F.
Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution
Structure
6
1185-1193
1998
Staphylococcus aureus, Staphylococcus aureus V8-BC 10
Manually annotated by BRENDA team
Sieprawska-Lupa, M.; Mydel, P.; Krawczyk, K.; Wojcik, K.; Puklo, M.; Lupa, B.; Suder, P.; Silberring, J.; Reed, M.; Pohl, J.; Shafer, W.; McAleese, F.; Foster, T.; Travis, J.; Potempa, J.
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases
Antimicrob. Agents Chemother.
48
4673-4679
2004
Staphylococcus aureus
Manually annotated by BRENDA team
Calander, A.M.; Jonsson, I.M.; Kanth, A.; Arvidsson, S.; Shaw, L.; Foster, S.J.; Tarkowski, A.
Impact of staphylococcal protease expression on the outcome of infectious arthritis
Microbes Infect.
6
202-206
2004
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Manually annotated by BRENDA team
Beaufort, N.; Wojciechowski, P.; Sommerhoff, C.P.; Szmyd, G.; Dubin, G.; Eick, S.; Kellermann, J.; Schmitt, M.; Potempa, J.; Magdolen, V.
The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin
Biochem. J.
410
157-165
2008
Staphylococcus aureus
Manually annotated by BRENDA team
Calander, A.M.; Dubin, G.; Potempa, J.; Tarkowski, A.
Staphylococcus aureus infection triggers production of neutralizing, V8 protease-specific antibodies
FEMS Immunol. Med. Microbiol.
52
267-272
2008
Staphylococcus aureus
Manually annotated by BRENDA team
Oscarsson, J.; Tegmark-Wisell, K.; Arvidson, S.
Coordinated and differential control of aureolysin (aur) and serine protease (sspA) transcription in Staphylococcus aureus by sarA, rot and agr (RNAIII)
Int. J. Med. Microbiol.
296
365-380
2006
Staphylococcus aureus
Manually annotated by BRENDA team
Nickerson, N.N.; Prasad, L.; Jacob, L.; Delbaere, L.T.; McGavin, M.J.
Activation of the SspA serine protease zymogen of Staphylococcus aureus proceeds through unique variations of a trypsinogen-like mechanism and is dependent on both autocatalytic and metalloprotease-specific processing
J. Biol. Chem.
282
34129-34138
2007
Staphylococcus aureus, Staphylococcus aureus RN4220
Manually annotated by BRENDA team
Sabat, A.J.; Wladyka, B.; Kosowska-Shick, K.; Grundmann, H.; van Dijl, J.M.; Kowal, J.; Appelbaum, P.C.; Dubin, A.; Hryniewicz, W.
Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureus strains
BMC Microbiol.
8
129
2008
Staphylococcus aureus
Manually annotated by BRENDA team
Nickerson, N.N.; Joag, V.; McGavin, M.J.
Rapid autocatalytic activation of the M4 metalloprotease aureolysin is controlled by a conserved N-terminal fungalysin-thermolysin-propeptide domain
Mol. Microbiol.
69
1530-1543
2008
Staphylococcus aureus
Manually annotated by BRENDA team
Schmidtchen, A.; Pasupuleti, M.; Moergelin, M.; Davoudi, M.; Alenfall, J.; Chalupka, A.; Malmsten, M.
Boosting antimicrobial peptides by hydrophobic oligopeptide end tags
J. Biol. Chem.
284
17584-17594
2009
Staphylococcus aureus
Manually annotated by BRENDA team
Kwak, Y.K.; Hoegbom, M.; Colque-Navarro, P.; Moellby, R.; Vecsey-Semjen, B.
Biological relevance of natural alpha-toxin fragments from Staphylococcus aureus
J. Membr. Biol.
233
93-103
2010
Staphylococcus aureus
Manually annotated by BRENDA team
Laarman, A.J.; Ruyken, M.; Malone, C.L.; van Strijp, J.A.; Horswill, A.R.; Rooijakkers, S.H.
Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion
J. Immunol.
186
6445-6453
2011
Staphylococcus aureus, Staphylococcus aureus KV27
Manually annotated by BRENDA team
Marti­, M.; Trotonda, M.; Tormo-Mas, M.; Vergara-Irigaray, M.; Cheung, A.; Lasa, I.; Penades, J.
Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus
Microbes Infect.
12
55-64
2010
Staphylococcus aureus
Manually annotated by BRENDA team
Zdzalik, M.; Karim, A.; Wolski, K.; Buda, P.; Wojcik, K.; Brueggemann, S.; Wojciechowski, P.; Eick, S.; Calander, A.; Jonsson, I.; Kubica, M.; Polakowska, K.; Miedzobrodzki, J.; Wladyka, B.; Potempa, J.; Dubin, G.
Prevalence of genes encoding extracellular proteases in Staphylococcus aureus - important targets triggering immune response in vivo
FEMS Immunol. Med. Microbiol.
66
220-229
2012
Staphylococcus aureus (Q2FUX4), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FUX4)
Manually annotated by BRENDA team
Kantyka, T.; Pyrc, K.; Gruca, M.; Smagur, J.; Plaza, K.; Guzik, K.; Zeglen, S.; Ochman, M.; Potempa, J.
Staphylococcus aureus proteases degrade lung surfactant protein a potentially impairing innate immunity of the lung
J. Innate Immun.
5
251-260
2013
Staphylococcus aureus
Manually annotated by BRENDA team
Jusko, M.; Potempa, J.; Kantyka, T.; Bielecka, E.; Miller, H.; Kalinska, M.; Dubin, G.; Garred, P.; Shaw, L.; Blom, A.
Staphylococcal proteases aid in evasion of the human complement system
J. Innate Immun.
6
31-46
2014
Staphylococcus aureus, Staphylococcus aureus V8-BC10
Manually annotated by BRENDA team
Yokoi, K.J.; Kuzuwa, S.; Iwasaki, S.; Yamakawa, A.; Taketo, A.; Kodaira, K.
Aureolysin of Staphylococcus warneri M accelerates its proteolytic cascade, and participates in biofilm formation
Biosci. Biotechnol. Biochem.
80
1238-1242
2016
Staphylococcus warneri (A0A0K2QQX9), Staphylococcus warneri, Staphylococcus warneri M (A0A0K2QQX9)
Manually annotated by BRENDA team
Elmwall, J.; Kwiecinski, J.; Na, M.; Ali, A.A.; Osla, V.; Shaw, L.N.; Wang, W.; Saevman, K.; Josefsson, E.; Bylund, J.; Jin, T.; Welin, A.; Karlsson, A.
Galectin-3 is a target for proteases involved in the virulence of Staphylococcus aureus
Infect. Immun.
85
e00177-17
2017
Staphylococcus aureus (Q2FZL2), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FZL2)
Manually annotated by BRENDA team
Austin, C.M.; Garabaglu, S.; Krute, C.N.; Ridder, M.J.; Seawell, N.A.; Markiewicz, M.A.; Boyd, J.M.; Bose, J.L.
Contribution of YjbIH to virulence factor expression and host colonization in Staphylococcus aureus
Infect. Immun.
87
e00155-19
2019
Staphylococcus aureus (P81177), Staphylococcus aureus
Manually annotated by BRENDA team
Lehman, M.K.; Nuxoll, A.S.; Yamada, K.J.; Kielian, T.; Carson, S.D.; Fey, P.D.
Protease-mediated growth of Staphylococcus aureus on host proteins is opp3 dependent
mBio
10
e02553-18
2019
Staphylococcus aureus (P81177), Staphylococcus aureus
Manually annotated by BRENDA team