3.4.24.13: IgA-specific metalloendopeptidase

This is an abbreviated version!
For detailed information about IgA-specific metalloendopeptidase, go to the full flat file.

Reaction

Cleavage of Pro-/-Thr bond in the hinge region of the heavy chain of human IgA =

Synonyms

HP1022, Iga, IgA protease, IgA protease A2, IgA protease B1, IgA1 protease, IgA1 proteinase, IgA1-protease, IgA1-specific proteinase, IgA1P, IgA1pr, igA2, IgaA2, igaB, igaB1, IgaB2, immunoglobulin A1 protease, proteinase, immunoglobulin A1, Streptococcus pneumoniae IgA1 protease, zinc metalloprotease zmpC

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.13 IgA-specific metalloendopeptidase

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Results	in table
742	AA Sequence
12	Application
1	CAS Registry Number
23	Cloned(Commentary)
16	General Information
1	General Stability
14	IC50 Value
72	Inhibitors
1	KM Value [mM]
13	Localization
14	Metals/Ions
10	Molecular Weight [Da]
83	Natural Substrates/ Products (Substrates)
213	Organism
3	PDB ID
4	pH Optimum
1	pH Range
2	pH Stability
6	Posttranslational Modification
27	Protein Variants
13	Purification (Commentary)
2	Reaction
2	Reaction Type
187	Reference
3	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
243	Substrates and Products (Substrate)
8	Subunits
105	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

IC50 Value

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IC50 Value on EC 3.4.24.13 - IgA-specific metalloendopeptidase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.962

1,2-diethyl-3-hydroxypyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.887

1-ethyl-3-hydroxy-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.00614

1-[2-(3-bromophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.00498

1-[2-(3-chloro-4-methoxyphenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.0043

1-[2-(3-chlorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.00774

1-[2-(3-fluorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

1.3

3-hydroxy-1,2-dimethylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.00664

3-hydroxy-1-[2-(3-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.007

3-hydroxy-1-[2-(4-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.0127

3-hydroxy-2-methyl-1-(2-phenylethyl)pyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.00914

3-hydroxy-2-methyl-1-[2-(3-methylphenyl)ethyl]pyridine-4(1H)-thione

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.0523

Berberine

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.152

norharmane

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982

0.0231

remerine

Streptococcus pneumoniae

-

in 50 mM Tris-HCl, pH 7.0, at 37°C

731982