3.4.24.13: IgA-specific metalloendopeptidase
This is an abbreviated version!
For detailed information about IgA-specific metalloendopeptidase, go to the full flat file.
Word Map on EC 3.4.24.13
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3.4.24.13
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medicine
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hinge
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gonorrhoeae
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influenzae
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haemophilus
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proteinases
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neisserial
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20-year
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colostrum
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nontypeable
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fcalpha
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hexxh
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meningitidis
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airways
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tetrapeptide
- 3.4.24.13
- medicine
- hinge
- gonorrhoeae
- influenzae
-
haemophilus
- proteinases
-
neisserial
-
20-year
-
colostrum
-
nontypeable
- fcalpha
-
hexxh
- meningitidis
- airways
- tetrapeptide
Reaction
Cleavage of Pro-/-Thr bond in the hinge region of the heavy chain of human IgA =
Synonyms
HP1022, Iga, IgA protease, IgA protease A2, IgA protease B1, IgA1 protease, IgA1 proteinase, IgA1-protease, IgA1-specific proteinase, IgA1P, IgA1pr, igA2, IgaA2, igaB, igaB1, IgaB2, immunoglobulin A1 protease, proteinase, immunoglobulin A1, Streptococcus pneumoniae IgA1 protease, zinc metalloprotease zmpC
ECTree
3.4.24.13 IgA-specific metalloendopeptidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.24.13 - IgA-specific metalloendopeptidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human immunoglobulin A1 + H2O
?
-
specific cleavage in the hinge region
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fc + immunoglobulin Fab
-
cleavage of the hinge region
-
-
?
immunoglobulin A1 + H2O
immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha
-
-
-
-
?
immunoglobulin IgA1 + H2O
effector domain of IgA1 + Fab determinants of IgA1
-
-
specific cleavage of hinge region. IgA1 bound to bacterial porin A is masked by the serogroup B polysaccharide capsule and less accessible to degradation. De novo synthesis of enzyme is required for degradation of porin-A-bound IgA1
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes. Infection of T84 monolayers also results in IgA1 protease-mediated reduction of LAMP1
-
?
LAMP1 + H2O
?
-
LAMP1 is a major integral membrane glycoprotein of lysosomes and significantly reduces its steady-state levels in an infected cell. Pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of LAMP1 accessible to IgA1 protease
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
retained antigen-binding activity of Fabalpha fragments of human monoclonal immunoglobulin A1 cleaved by IgA 1 protease opens the possibility that IgA1 protease-producing bacteria growing in the presence of IgA1 antibodies are coated with Fabalpha fragments. Such fragments may conceivably protect the microorganism from the immune system by blocking access of intact antibody molecules of the same or other isotypes and of immunocompetent cells
-
-
?
additional information
?
-
-
IgA1 protease of the Brazilian purpuric fever clone may contribute to the pathogenic potential of the virulent phenotype in Brazil
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the cleavage of IgA1 by gonococcal IgA1 protease within the lumen of the female lower genital tract is unlikely to be a significant factor in the pathogenesis of infections by Neisseria gonorrhoeae
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
Streptococcus mitior
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
potential impotance of IgA proteases as an ecological determinant in the oral cavity and their role as a determinant of pathogenesis of pathogenic bacteria whose portal of entry is the mucosal surface
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
