3.4.24.13: IgA-specific metalloendopeptidase

This is an abbreviated version!
For detailed information about IgA-specific metalloendopeptidase, go to the full flat file.

Reaction

Cleavage of Pro-/-Thr bond in the hinge region of the heavy chain of human IgA =

Synonyms

HP1022, Iga, IgA protease, IgA protease A2, IgA protease B1, IgA1 protease, IgA1 proteinase, IgA1-protease, IgA1-specific proteinase, IgA1P, IgA1pr, igA2, IgaA2, igaB, igaB1, IgaB2, immunoglobulin A1 protease, proteinase, immunoglobulin A1, Streptococcus pneumoniae IgA1 protease, zinc metalloprotease zmpC

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.13 IgA-specific metalloendopeptidase

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Results	in table
742	AA Sequence
12	Application
1	CAS Registry Number
23	Cloned(Commentary)
16	General Information
1	General Stability
14	IC50 Value
72	Inhibitors
1	KM Value [mM]
13	Localization
14	Metals/Ions
10	Molecular Weight [Da]
83	Natural Substrates/ Products (Substrates)
213	Organism
3	PDB ID
4	pH Optimum
1	pH Range
2	pH Stability
6	Posttranslational Modification
27	Protein Variants
13	Purification (Commentary)
2	Reaction
2	Reaction Type
187	Reference
3	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
243	Substrates and Products (Substrate)
8	Subunits
105	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

General Information

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General Information on EC 3.4.24.13 - IgA-specific metalloendopeptidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Haemophilus influenzae NTHI

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expression of IgA proteases is variable from strain to strain among NTHi. Analysis of IgA protease expression by 101 persistent strains (median duration of persistence) collected longitudinally from patients enrolled in a 20-year study of COPD upon initial acquisition and immediately before clearance from the host. Upon acquisition, 89 (88%) express IgA protease. A total of 16 of 101 (16%) strains of NTHi alter expression of IgA protease during persistence. Indels and slipped-strand mispairing of mononucleotide repeats confer changes in expression of igaA2. Mechanism of changes in expression, overview

753802

physiological function

9 entries

additional information

6 entries

physiological function

Streptococcus suis

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IgA1 protease may play an important role in the pathogenesis of Streptococcus suis

710668

physiological function

Streptococcus pneumoniae

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the enzyme catalyzes the proteolysis of human IgA1 at its hinge region to leave the bacterial cell surface masked by IgA1 Fab, enabling the bacteria to evade the host's immune system and adhere to host epithelial cells to promote colonization

731982

physiological function

Haemophilus influenzae NTHI

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enzyme IgA1P cleaves human immunoglobulin A1 (IgA1), the predominant antibody on human mucosal surfaces. The actions of IgA1Ps impede IgA1 from neutralizing the bacteria. Specifically, IgA1P cleaves IgA1 at a unique hinge region, separating the Fc and Fab fragments of the immunoglobulin. This impairs its Fc-mediated effector response and can even allow bacteria to retain the Fab fragment on their surface in order to mask their polysaccharide capsule and other surface antigens

752366

physiological function

Streptococcus pneumoniae

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IgA1 protease (IgA1P) specifically cleaves human immunoglobulin A1 (IgA1) at the hinge region dissociating the effector Fc region while the IgA1 FAB remains bound to the bacterial surface. This cleavage promotes infection by two mechanisms. Firstly, Fc receptors on neutrophils can no longer recognize the cleaved and released IgA1 Fc to bind and kill the bacterial cells. Secondly, the IgA1 FAB fragment remaining on the Streptococcus pneumoniae cell surface enhances Streptococcus pneumoniae binding to epithelial cells and can no longer prevent colonization

755335

physiological function

Haemophilus influenzae NTHI

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nontypeable Haemophilus influenzae (NTHi) expresses four IgA protease variants (A1, A2, B1, and B2) that play different roles in virulence

753802

physiological function

Streptococcus suis DAT1

A0A0Z8E9X6

the virulence-associated protein, IgA1 protease, is a surface protective antigen of SS2

754643

physiological function

Streptococcus suis DAT1 SC-19

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the virulence-associated protein, IgA1 protease, is a surface protective antigen of SS2

-

physiological function

Streptococcus suis DAT1 ZYS

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the virulence-associated protein, IgA1 protease, is a surface protective antigen of SS2

-

physiological function

Streptococcus suis 05ZYS

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IgA1 protease may play an important role in the pathogenesis of Streptococcus suis

-

additional information

Streptococcus suis DAT1

A0A0Z8E9X6

IgA1 protease is a surface protective antigen of Streptococcus suis serotype 2 (SS2), immunization with purified recombinant IgA1 protease (amino acid residues 600-1926) induces high IgG antibody titers and confers complete protection against a challenge with a lethal dose of SS2 in a BALB/c mouse model

754643

additional information

Neisseria meningitidis serogroup B

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immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including Neissseria meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from Neisseria meningitidis serogroup B are detected. Cross-reactive protection against meningococcal and pneumococcal infections in vivo

754644

additional information

Streptococcus pneumoniae

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the conserved HExxH motif (amino acid residues 1604-1608) coordinates Zn2+ and provides the catalytic base, Glu1605. Residue Glu1628 also contributes to IgA1P catalytic activity. The C-terminal domain, IgA1P1612-1963, exhibits no detectable binding to IgA1. The Streptococcus pneumoniae IgA1P N- and C-terminal regions are catalytically active when combined in trans

755335

additional information

Streptococcus suis DAT1 SC-19

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IgA1 protease is a surface protective antigen of Streptococcus suis serotype 2 (SS2), immunization with purified recombinant IgA1 protease (amino acid residues 600-1926) induces high IgG antibody titers and confers complete protection against a challenge with a lethal dose of SS2 in a BALB/c mouse model

-

additional information

Streptococcus suis DAT1 ZYS

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IgA1 protease is a surface protective antigen of Streptococcus suis serotype 2 (SS2), immunization with purified recombinant IgA1 protease (amino acid residues 600-1926) induces high IgG antibody titers and confers complete protection against a challenge with a lethal dose of SS2 in a BALB/c mouse model

-

additional information

Neisseria meningitidis serogroup B B44/76

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immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including Neissseria meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from Neisseria meningitidis serogroup B are detected. Cross-reactive protection against meningococcal and pneumococcal infections in vivo

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