3.4.23.B9: bovine leukemia virus protease

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For detailed information about bovine leukemia virus protease, go to the full flat file.

Reaction

The best substrate YDPPAILPII is bearing the natural cleavage site between the matrix and the capsid proteins of BLV Gag precursor. polyprotein. Good cleavage of the peptide bonds: Leu-Pro, Leu-Val, Gly-Val and Leu-Pro =

Synonyms

BLV endopeptidase, BLV PR, BLV protease, bovine leukemia virus protease, bovine leukemia virus retropepsin, BVL PR, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B9 bovine leukemia virus protease

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Results	in table
2	Activating Compound
1	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
12	IC50 Value
29	Inhibitors
14	Ki Value [mM]
45	KM Value [mM]
1	Localization
5	Metals/Ions
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
10	Organism
4	pH Optimum
2	pH Range
1	pH Stability
1	pI Value
2	Posttranslational Modification
4	Protein Variants
4	Purification (Commentary)
3	Reaction
1	Reaction Type
10	Reference
1	Specific Activity [micromol/min/mg]
80	Substrates and Products (Substrate)
4	Subunits
14	Synonyms
4	Temperature Optimum [°C]
2	Temperature Range [°C]
50	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.B9 - bovine leukemia virus protease

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Gag polyprotein + H2O

?

2 entries

Gag-Pol polyprotein + H2O

?

2 entries

additional information

?

-

bovine leukemia virus

-

the enzyme is responsible for processing both the initial translation products - precursors Gag-Pro-Pol, Gag-Pro and Gag into functional enzymes - protease, reverse transcriptase and integrase - and the mature structural proteins of the matrix, capsid and nucleocapsid

647864

-

-

?

Gag polyprotein + H2O

?

bovine leukemia virus

-

processing of the precursor protein into mature structural proteins of the matrix, capsid, and nucleocapsid, and the functional protease

668796

-

-

?

Gag polyprotein + H2O

?

bovine leukemia virus BLV

-

processing of the precursor protein into mature structural proteins of the matrix, capsid, and nucleocapsid, and the functional protease

668796

-

-

?

Gag-Pol polyprotein + H2O

?

bovine leukemia virus

-

processing of the precursor protein into mature structural proteins of the matrix, capsid, and nucleocapsid, and the functional protease

668796

-

-

?

Gag-Pol polyprotein + H2O

?

bovine leukemia virus BLV

-

processing of the precursor protein into mature structural proteins of the matrix, capsid, and nucleocapsid, and the functional protease

668796

-

-

?