3.4.23.B9: bovine leukemia virus protease

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For detailed information about bovine leukemia virus protease, go to the full flat file.

Reaction

The best substrate YDPPAILPII is bearing the natural cleavage site between the matrix and the capsid proteins of BLV Gag precursor. polyprotein. Good cleavage of the peptide bonds: Leu-Pro, Leu-Val, Gly-Val and Leu-Pro =

Synonyms

BLV endopeptidase, BLV PR, BLV protease, bovine leukemia virus protease, bovine leukemia virus retropepsin, BVL PR, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B9 bovine leukemia virus protease

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Results	in table
2	Activating Compound
1	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
12	IC50 Value
29	Inhibitors
14	Ki Value [mM]
45	KM Value [mM]
1	Localization
5	Metals/Ions
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
10	Organism
4	pH Optimum
2	pH Range
1	pH Stability
1	pI Value
2	Posttranslational Modification
4	Protein Variants
4	Purification (Commentary)
3	Reaction
1	Reaction Type
10	Reference
1	Specific Activity [micromol/min/mg]
80	Substrates and Products (Substrate)
4	Subunits
14	Synonyms
4	Temperature Optimum [°C]
2	Temperature Range [°C]
50	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.23.B9 - bovine leukemia virus protease

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.25

Ac-PQVL-azetidine-VM

bovine leukemia virus

-

IC50: 0.25 mM

647864

0.015

Ac-PQVL-pipecolic acid-VM

bovine leukemia virus

-

IC50: 0.015 mM

647864

0.25

Ac-Pro-Glu-Val-Leu-azetidine-Val-Met

bovine leukemia virus

-

IC50: 0.250 mM

668796

0.015

Ac-Pro-Glu-Val-Leu-pipecolic acid-Val-Met

bovine leukemia virus

-

IC50: 0.015 mM

668796

5

cerulenin

bovine leukemia virus

-

IC50: 5 mM

668796

0.1

Gly-Val-Leu-Tyr-statine-Glu-Ala

bovine leukemia virus

-

IC50: 0.10 mM

668796

0.3 - 0.5

pepstatin A

bovine leukemia virus

-

IC50: 0.3-0.5 mM

647864, 668796

0.1

PQV-statine-AI

bovine leukemia virus

-

IC50: 0.1 mM

647864

0.1

Pro-Glu-Val-statine-Ala-Leu

bovine leukemia virus

-

IC50: 0.10 mM

668796

0.0005

YDPPAI-statine-II

2 entries

0.0005

YDPPAI-statine-II

bovine leukemia virus

-

IC50: 0.0005 mM

647864

0.0005

YDPPAI-statine-II

bovine leukemia virus

-

strong inhibition, IC50: 0.0005 mM

668796