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3.4.23.B24: signal peptide peptidase

This is an abbreviated version!
For detailed information about signal peptide peptidase, go to the full flat file.

Word Map on EC 3.4.23.B24

Reaction

intramembrane cleavage of signal peptides =

Synonyms

ANID_08681, aspartic intramembrane protease, Hm13, hSPP, minor histocompatibility antigen H13, PF3D7_1457000, PlSPP, signal peptide peptidase like 2a, signal peptide peptidase-like 2a, signal peptide peptidase-like 2B, signal peptide peptidase-like 2C, signal peptide peptidase-like 3, SPP, SPP-like 2A, SPP-like 2B, SPP-like 2C, SPP-like 3, SPP1, SppA, SPPL, SPPL2a, SPPL2b, SPPL2c, UMAG_02729

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B24 signal peptide peptidase

IC50 Value

IC50 Value on EC 3.4.23.B24 - signal peptide peptidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00285
(2R)-2-methyl-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]-N4-[2-(trifluoromethyl)phenyl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.000035
(2R)-2-methyl-N4-(2-methylphenyl)-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.00102
(2R)-2-methyl-N4-(2-methylpyridin-3-yl)-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.00007
(2R)-2-methyl-N4-(3-methylphenyl)-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.00139
(2R)-2-methyl-N4-(4-methylphenyl)-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.00087
(2R)-N1-[(10S)-5,11-dioxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]-N4-(5-fluoro-2-methylpyridin-3-yl)-2-methylbutanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.000005
(2R)-N4-(3,5-difluorophenyl)-2-methyl-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.000044
(2R)-N4-(5-fluoro-2-methylpyridin-3-yl)-2-methyl-N1-[(10S)-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.000076
(2R)-N4-(5-fluoro-2-methylpyridin-3-yl)-N1-[(10S)-6-fluoro-11-oxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]-2-methylbutanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.000077
(2S)-2-cyclopropyl-N1-[(10'S)-5',11'-dioxo-10',11'-dihydro-5'H-spiro[cyclopropane-1,2'-pyrazolo[1,2-b][2,3]benzodiazepin]-10'-yl]-N4-(5-fluoro-2-methylpyridin-3-yl)butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.000225
(2S)-2-cyclopropyl-N1-[(10S)-5,11-dioxo-2,3,10,11-tetrahydro-1H,5H-pyrazolo[1,2-b][2,3]benzodiazepin-10-yl]-N4-(5-fluoro-2-methylpyridin-3-yl)butanediamide
Homo sapiens
pH 7.4, 37°C, liver microsomes
-
0.00146
(S,S)-2-[2-(3,5-difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000177 - 0.006
2,2'-(2-oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide]
0.000423 - 0.0088
GSI II
0.000161 - 0.000876
L685,458
0.000051 - 0.01
LY-411,575
0.000948
N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Homo sapiens
-
pH and temperature not specified in the publication