3.4.23.B24: signal peptide peptidase

This is an abbreviated version!
For detailed information about signal peptide peptidase, go to the full flat file.

Reaction

intramembrane cleavage of signal peptides =

Synonyms

ANID_08681, aspartic intramembrane protease, Hm13, hSPP, minor histocompatibility antigen H13, PF3D7_1457000, PlSPP, signal peptide peptidase like 2a, signal peptide peptidase-like 2a, signal peptide peptidase-like 2B, signal peptide peptidase-like 2C, signal peptide peptidase-like 3, SPP, SPP-like 2A, SPP-like 2B, SPP-like 2C, SPP-like 3, SPP1, SppA, SPPL, SPPL2a, SPPL2b, SPPL2c, UMAG_02729

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B24 signal peptide peptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
13	AA Sequence
12	Application
16	Cloned(Commentary)
2	Crystallization (Commentary)
117	Disease/ Diagnostics
4	Expression
46	General Information
31	IC50 Value
64	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
19	Localization
8	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
41	Organism
1	pH Optimum
27	Protein Variants
1	Reaction
36	Reference
49	Source Tissue
57	Substrates and Products (Substrate)
17	Subunits
65	Synonyms
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Expression

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Expression on EC 3.4.23.B24 - signal peptide peptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Expression Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

EXPRESSION

ORGANISM

UNIPROT

LITERATURE

SPP expression is highly induced in human lung and breast cancers and correlated with disease outcome

Homo sapiens

-

754940

spp1 belongs to the unfolded protein response (UPR) core genes identified under stringent filtering criteria and expression of spp1 is strongly induced in planta. Activation of the UPR is connected to the control of fungal proliferation through direct protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. This interaction leads to functional modification of Cib1 and modulation of UPR gene expression to adapt the UPR for long-term activity in the plant

3 entries

spp1 belongs to the unfolded protein response (UPR) core genes identified under stringent filtering criteria and expression of spp1 is strongly induced in planta. Activation of the UPR is connected to the control of fungal proliferation through direct protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. This interaction leads to functional modification of Cib1 and modulation of UPR gene expression to adapt the UPR for long-term activity in the plant

Ustilago maydis

A0A0D1E4M7

755217

spp1 belongs to the unfolded protein response (UPR) core genes identified under stringent filtering criteria and expression of spp1 is strongly induced in planta. Activation of the UPR is connected to the control of fungal proliferation through direct protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. This interaction leads to functional modification of Cib1 and modulation of UPR gene expression to adapt the UPR for long-term activity in the plant

Ustilago maydis 521

-

-

spp1 belongs to the unfolded protein response (UPR) core genes identified under stringent filtering criteria and expression of spp1 is strongly induced in planta. Activation of the UPR is connected to the control of fungal proliferation through direct protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. This interaction leads to functional modification of Cib1 and modulation of UPR gene expression to adapt the UPR for long-term activity in the plant

Ustilago maydis FGSC 9021

-

-