3.4.23.B20: HycD peptidase

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For detailed information about HycD peptidase, go to the full flat file.

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This enzyme specifically removes a 15-amino acid peptide from the C-terminus of the precursor of the large subunit of hydrogenase 2 [UniProt: P0ACE0] in Escherichia coli =

Synonyms

endopeptidase of the hydrogenase 2 operon, HYBD, hydrogenase maturating endopeptidase HYBD, HypD

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.B20 HycD peptidase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	Metals/Ions
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
5	Organism
2	Purification (Commentary)
1	Reaction
5	Reference
6	Substrates and Products (Substrate)
1	Subunits
7	Synonyms

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.B20 - HycD peptidase

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precursor of the large subunit of hydrogenase 2 + H2O

Escherichia coli

P37182

the final step of maturation of [NiFe]-hydrogenases involves the activity of an endopeptidase which removes an oligopeptide from the C-terminus of the large subunit of hydrogenase 2 (UniProt: P0ACE0). The proteolytic maturation is followed by a conformational change, closing of the metal centre, its assembly with the small hydrogenase subunit and finally in the appearance of enzyme activity

690862

precursor of the large subunit of hydrogenase 2 + H2O

large subunit of hydrogenase 2 + propeptide of hydrogenase 2

Escherichia coli

P37182

the maturation of [NiFe] hydrogenases includes formation of the nickel metallocenter, proteolytic processing of the metal center carrying large subunit, and its assembling with other hydrogenase subunits. The hydrogenase maturating enzyme HYBD specifically cleaves off a 15 amino acid peptide from the C terminus of the precursor of the large subunit of hydrogenase 2 (UniProt: P0ACE0)

693609