3.4.23.35: Barrierpepsin
This is an abbreviated version!
For detailed information about Barrierpepsin, go to the full flat file.
Word Map on EC 3.4.23.35
Reaction
Selective cleavage of -Leu6-/-Lys- bond in the pheromone alpha-mating factor =
Synonyms
Bar proteinase, Barrier proteinase, Extracellular "barrier" protein, More
ECTree
3.4.23.35 BarrierpepsinAdvanced search results
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Substrates Products on EC 3.4.23.35 - Barrierpepsin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
His-Trp-Leu-Gln-Leu-Arg-Pro-Gly-Gln-Pro-Met-Tyr + H2O
His-Trp-Leu-Gln-Leu + Arg-Pro-Gly-Gln-Pro-Met-Tyr
-
cleavage site: Leu-Arg
-
-
?
His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr + H2O
His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
cleavage site: Leu-Lys
-
-
?
Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr + H2O
Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
cleavage site: Leu-Lys
-
-
?
alpha Factor + H2O
?
-
i.e. Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, involved in physiological changes preceding Saccharomyces cerevisiae cell fusion
-
-
?
alpha Factor + H2O
?
-
acts as antagonist of alpha factor, the peptide mating pheromone produced by mating type alpha-cells
-
-
?
alpha Factor + H2O
Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
cleavage site: Leu6-Lys7
-
?
alpha Factor + H2O
Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
cleavage site: Leu6-Lys7
-
-
?
alpha Factor + H2O
Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
strict substrate specificity
-
-
?
alpha Factor + H2O
Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
i.e. Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, a Saccharomyces cerevisiae peptide mating pheromone secreted by mating-type alpha cells
-
?
alpha Factor + H2O
Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
i.e. Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, a Saccharomyces cerevisiae peptide mating pheromone secreted by mating-type alpha cells
-
-
?
WHWLQLKQGQPMY + H2O
WHWLQL + KQGQPMY
-
absolutely specific for the single neutral substrate peptide pheromone alpha-factor
-
-
?
WHWLQLKQGQPMY + H2O
WHWLQL + KQGQPMY
-
absolutely specific for the single neutral substrate peptide pheromone alpha-factor, commercial substrate preparation
-
-
?
WHWLQLKQGQPMY + H2O
WHWLQL + KQGQPMY
-
absolutely specific for the single neutral substrate peptide pheromone alpha-factor
-
-
?
WHWLQLKQGQPMY + H2O
WHWLQL + KQGQPMY
-
absolutely specific for the single neutral substrate peptide pheromone alpha-factor, commercial substrate preparation
-
-
?
additional information
?
-
-
requires at least 4 amino acid residues on N-terminal and more than 4 on C-terminal side
-
-
?
additional information
?
-
-
no hydrolysis of alpha factor derived peptides Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln, Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln, Trp-Leu-Gln-Leu-Lys-Pro-Gly
-
-
?
additional information
?
-
-
Leu-Gln-Leu-Lys, Leu-Gln-Leu-Lys-Pro, Trp-Leu-Gln-Leu, His-Trp-Leu-Gln-Leu, Trp-Leu-Gln-Leu-Lys, Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro, Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-lactone, Saccharomyces kluyveri alpha factor, tosyl-L-Lys chloromethylketone, tosyl-L-Arg methyl ester, 1,2-epoxy-3-(4-nitrophenoxy)propane, diazoacetyl-DL-norleucine ester, pepstatin
-
-
?
additional information
?
-
-
the reduced and alkylated B-chain of platelet-derived growth factor, synthetic peptides Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu, Ala-Pro-Ala-Lys-Phe-(4-nitro)Phe-Arg-Leu, Arg-Phe-Leu-Glu-(4-nitro)Phe-Lys-Pro-Gly-Gln-Pro, Lys-Pro-Glu-Ile-(4-nitro)Phe-Lys-Ser-Glu-Lys-Ile
-
-
?
