3.4.23.28: Acrocylindropepsin

This is an abbreviated version!
For detailed information about Acrocylindropepsin, go to the full flat file.

Word Map on EC 3.4.23.28

3.4.23.28

3.4.23.6

proteinases

r-factors

endothiapepsin

renin

rhizopuspepsin

pepstatin

rhizopus

beta-hairpins

root-mean-square

scissile

hydroxyethylene

non-hydrogen

penicillopepsin

statine-containing

Reaction

Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6-/-Cys(SO3H), Glu21-/-Arg and Asn3-/-Gln, although not Gln4-His =

Synonyms

Acrocylindricum proteinase, Acrocylindrium acid proteinase, Acrocylindrium proteinase, EC 3.4.23.6, EC 3.4.4.17, EC 3.4.99.1, More, Proteinase, Acrocylindricum

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.28 Acrocylindropepsin

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Results	in table
7	AA Sequence
1	CAS Registry Number
2	Crystallization (Commentary)
6	Inhibitors
1	Localization
3	Natural Substrates/ Products (Substrates)
3	Organism
1	pH Optimum
1	pH Stability
1	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
8	Synonyms
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.4.23.28 - Acrocylindropepsin

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casein + H2O

Acrocylindrium sp.

high activity

668811

FVNQHLCGSHLVEALYLVCGERGFFYTPKA + 6 H2O

FVNQHL + CGSHL + VEAL + L-Tyr + LVCGERGF + L-Phe + YTPKA

Acrocylindrium sp.

i.e. insulin B chain, cleavage site specificity

668811

Glucagon + H2O

2 entries

insulin A chain + H2O

Acrocylindrium sp.

cleavage site specificity

668811

Oxidized insulin A-chain + H2O

Acrocylindrium sp.

complete hydrolysis of Leu13-Tyr14, partial hydrolysis of Leu16-Glu17 and Glu17-Asn18, some hydrolysis of Tyr14-Glu15 and Tyr19-Cys*SO3H2O

30726

Oxidized insulin B-chain + H2O

Acrocylindrium sp.

complete hydrolysis of: Leu6-Cys*SO3H7, Leu11-Val12, Leu15-Tyr16, Tyr16-Leu17, Phe24-Phe25, partial hydrolysis of: Asn3-Gln4, Ala14-Leu15, Gly20-Glu21, Glu21-Arg22, Tyr26-Thr27

30726

additional information

Acrocylindrium sp.

the enzyme prefers Tyr, Phe, or Leu at P1 or P1' positions

668811