3.4.23.28: Acrocylindropepsin

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For detailed information about Acrocylindropepsin, go to the full flat file.

Reaction

Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6-/-Cys(SO3H), Glu21-/-Arg and Asn3-/-Gln, although not Gln4-His =

Synonyms

Acrocylindricum proteinase, Acrocylindrium acid proteinase, Acrocylindrium proteinase, EC 3.4.23.6, EC 3.4.4.17, EC 3.4.99.1, More, Proteinase, Acrocylindricum

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.28 Acrocylindropepsin

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Results	in table
7	AA Sequence
1	CAS Registry Number
2	Crystallization (Commentary)
6	Inhibitors
1	Localization
3	Natural Substrates/ Products (Substrates)
3	Organism
1	pH Optimum
1	pH Stability
1	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
8	Synonyms
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.28 - Acrocylindropepsin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

FVNQHLCGSHLVEALYLVCGERGFFYTPKA + 6 H2O

FVNQHL + CGSHL + VEAL + L-Tyr + LVCGERGF + L-Phe + YTPKA

Acrocylindrium sp.

-

i.e. insulin B chain, cleavage site specificity

668811

-

-

?

Glucagon + H2O

?

Acrocylindrium sp.

-

-

668811

-

-

?

insulin A chain + H2O

?

Acrocylindrium sp.

-

cleavage site specificity

668811

-

-

?