3.4.23.19: Aspergillopepsin II

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For detailed information about Aspergillopepsin II, go to the full flat file.

Reaction

preferential cleavage in B chain of insulin: Asn3-/-Gln, Gly13-/-Ala, Tyr26-/-Thr =

Synonyms

acid proteinase, acid proteinase A, AGP, aspergilloglutamic peptidase, Aspergillus niger var. macrosporus aspartic proteinase, Aspergillus proteinase A, EC 3.4.23.6, More, non-pepsin type acid proteinase, Proctase A, Proteinase A

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.19 Aspergillopepsin II

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Results	in table
14	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Crystallization (Commentary)
12	Inhibitors
2	Ki Value [mM]
5	KM Value [mM]
4	Localization
1	Molecular Weight [Da]
16	Organism
6	PDB ID
8	pH Optimum
2	pH Range
1	pH Stability
4	Posttranslational Modification
43	Protein Variants
7	Purification (Commentary)
4	Reaction
1	Reaction Type
16	Reference
1	Renatured (Commentary)
2	Source Tissue
1	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
2	Subunits
33	Synonyms
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
5	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.23.19 - Aspergillopepsin II

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

cDNA cloning with pAR2113, Escherichia coli BL21(DE) expression system

Aspergillus niger

-

649269

DNA and amino acid sequence determination and analysis, expression in Escherichia coli

Aspergillus niger var. macrosporus

-

668805

expression of wild-type and mutant enzymes

Aspergillus niger var. macrosporus

-

668592

wild-type and mutant pro-enzymes expressed in Escherichia coli

Aspergillus niger

-

652032