3.4.23.19: Aspergillopepsin II
This is an abbreviated version!
For detailed information about Aspergillopepsin II, go to the full flat file.
Word Map on EC 3.4.23.19
Reaction
preferential cleavage in B chain of insulin: Asn3-/-Gln, Gly13-/-Ala, Tyr26-/-Thr =
Synonyms
acid proteinase, acid proteinase A, AGP, aspergilloglutamic peptidase, Aspergillus niger var. macrosporus aspartic proteinase, Aspergillus proteinase A, EC 3.4.23.6, More, non-pepsin type acid proteinase, Proctase A, Proteinase A
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3.4.23.19 Aspergillopepsin IIAdvanced search results
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Substrates Products on EC 3.4.23.19 - Aspergillopepsin II
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Hemoglobin + H2O
Hydrolyzed hemoglobin
-
acid denatured hemoglobin
-
?
oxidized insulin B chain + H2O
FVN + QHLCGSHLVE + ALYLVCGERGFFY + TPKA
-
substrate from Bos taurus, cleavage site specificity
-
-
?
oxidized pancreatic ribonuclease A + H2O
?
-
substrate from Bos taurus
-
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
-
major cleavage sites: Asn3-Gln4, Glu13-Ala14, Tyr26-Thr27, minor site: Gly20-Glu21
-
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
-
major cleavage sites: Asn3-Gln4, Glu13-Ala14, Tyr26-Thr27, minor site: Gly20-Glu21
-
?
additional information
?
-
-
enzyme seems to cleave only peptides which contain large residues at p2 site, hardly influenced by the charges of the residues
-
?
additional information
?
-
-
the enzyme is a non-pepsin-type acid proteinase, and shows a primary specificity for Tyr, Phe, His, Asn, Asp, Gln, and Glu at P1 position, cleavage site specificity overview
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-
?
