3.4.21.97: assemblin

This is an abbreviated version!
For detailed information about assemblin, go to the full flat file.

Word Map on EC 3.4.21.97

3.4.21.97

viruses

genital

acyclovir

infectious

women

ganglia

transmitted

virion

thymidine

encephalitis

plaque

corneal

trigeminal

ocular

herpesviruses

keratitis

igg

herpetic

vaginal

seropositive

immunodeficiency

serological

immediate-early

type-1

ulcer

seroprevalence

type-specific

lytic

epstein-barr

chlamydia

tegument

neurotropic

cytopathic

oncolytic

syphilis

intravaginal

swab

postinfection

virus-specific

microbicide

replication-defective

seronegative

co-infection

ganciclovir

superinfect

pseudorabies

mucocutaneous

analysis

intercourse

medicine

heterosexual

cervicovaginal

Reaction

Cleaves -Ala-/-Ser- and -Ala-/-Ala- bonds in the scaffold protein =

Synonyms

Assemblin, assembly protein precursor-processing proteinase, capsid scaffolding protein, cytomegalovirus protease, cytomegalovius maturational protease, cytomeglovirus protease, HCMV protease, Herpes simplex virus 1 proteinase Pra, Herpes simplex virus endopeptidase, HHV-6 proteinase, hMCV, HSV 1 protease, HSV-1, HSV-1 protease, HSV-2, human cytomegalovirus maturational protease, human cytomegalovirus maturational proteinase, human cytomegalovirus protease, human cytomegalovirus proteinase, maturation proteinase, proteinase, assembly protein precursor-processing, pUL80a, SFA, Varicella-zoster virus gene 33 proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.97 assemblin

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Results	in table
3	Activating Compound
1132	AA Sequence
3	Application
1	CAS Registry Number
14	Cloned(Commentary)
16	Crystallization (Commentary)
1	General Information
1	General Stability
95	IC50 Value
120	Inhibitors
38	Ki Value [mM]
46	KM Value [mM]
8	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
72	Organism
38	PDB ID
6	pH Optimum
1	pH Range
2	pI Value
4	Posttranslational Modification
30	Protein Variants
8	Purification (Commentary)
2	Reaction
72	Reference
1	Source Tissue
4	Storage Stability
47	Substrates and Products (Substrate)
12	Subunits
49	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
44	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.97 - assemblin

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0.00018

(2S)-2-[[(3aS,6S,6aR)-4-(1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00018 mM

652751

0.00029

(2S)-2-[[(3aS,6S,6aR)-4-(4-chloro-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00029 mM

652751

0.00024

(2S)-2-[[(3aS,6S,6aR)-4-(4-methoxy-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00024 mM

652751

0.0011

(2S)-2-[[(3aS,6S,6aR)-4-(4-methoxy-7-methyl-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]-pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0011 mM

652751

0.00046

(2S)-2-[[(3aS,6S,6aR)-4-(5-chloro-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00046 mM

652751

0.00023

(2S)-2-[[(3aS,6S,6aR)-4-(5-methoxy-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00023 mM

652751

0.00087

(2S)-2-[[(3aS,6S,6aR)-4-(5-methoxy[1,3]thiazolo[5,4-b]-pyridin-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00087 mM

652751

0.00035

(2S)-2-[[(3aS,6S,6aR)-4-(6-ethylcarboxylate-1,2-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]-pyrrol-1(2H)yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00035 mM

652751

0.00036

(2S)-2-[[(3aS,6S,6aR)-4-(6-fluoro-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00036 mM

652751

0.00022

(2S)-2-[[(3aS,6S,6aR)-4-(6-methoxy-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00022 mM

652751

0.00018

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-meth-yl5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropoxyphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00018 mM

652751

0.00065

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(1-naphthyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00065 mM

652751

0.0014

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(3-chlorophenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0014 mM

652751

0.00026

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-chlorophenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00026 mM

652751

0.0002

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0002 mM

652751

0.00021

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-propoxyphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00021 mM

652751

0.00023

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-[4-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00023 mM

652751

0.0003

(2S)-2-[[(3aS,6S,6aR)-4-[(-cis-2,3-dimethylcyclopropyl)-cis-carbony]-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0003 mM

652751

0.0018

(2S)-2-[[(3aS,6S,6aR)-4-[(-cis-2,3-dimethylcyclopropyl)-trans-carbonyl]-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0018 mM

652751

0.00021

(2S)-2-[[(3aS,6S,6aR)-4-[5-[(difluoromethyl)sulfonyl]-1,3-benzothiazol-2-yl]-6-methyl-5-oxohexahydropyrrolo-[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)-pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00021 mM

652751

0.00031

(2S)-2-[[(3aS,6S,6aR)-4-[6-(hydroxymethyl)-1,3-benzothiazol-2-yl]-6-methyl-5-oxohexahydropyrrolo[3,2-b]-pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00031 mM

652751

0.0087

(2S)-2-[[(3aS,6S,6aR)-6-methyl-4-(4-nitrophenyl)-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0087 mM

652751

0.00039

(2S)-2-[[(3aS,6S,6aR)-6-methyl-4-(6-nitro-1,3-benzothiazol-2-yl)-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00039 mM

652751

0.0015

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-(1,3-thiazol-2-yl)hexahydropyrrolo[3,2-b]pyrrol-1(2H)yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.0015 mM

652751

0.02

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: above 0.02 mM

652751

0.00029

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-[1,3]thiazolo-[5,4-b]pyridin-2-ylhexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00029 mM

652751

0.00046

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

IC50: 0.00046 mM

652751

(3aR,6R,6aS)-4-Acetyl-6-methyl-5-oxohexahydropyrrolo-[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 1 mM

652734

0.006

(3aS,6S,6aR)-4-(2-Etoxy-acetyl)-6-methyl-5-oxohexahydropyrrolo-[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.006 mM

652734

0.11 - 0.79

(3aS,6S,6aR)-4-Acetyl-6-methyl-5-oxohexahydropyrrolo-[3,2-b]pyrrole-1-carboxylic acid benzyl ester

2 entries

0.159

(3R,3aS,6aR)-1-Acetyl-3-methyl-4-([(2S)-1-[(4-methylphenyl) sulfonyl]pyrrolidin-2-yl]carbonyl)hexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.159 mM

652734

0.5

(3R,3aS,6aR)-1-Acetyl-4-[((2S)-1-[[5-(dimethylamino)-1-naphthyl] sulfonyl]pyrrolidin-2-yl)carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.5

(3R,3aS,6aR)-1-Acetyl-4-[[(2S)-1-benzoylpyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.00019

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-(2-naphthylsulfonyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: below 0.00019 mM

652751

0.00037

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-1-(1-naphthylsulfonyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00037 mM

652751

0.00054

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-1-(4-propoxybenzoyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00054 mM

652751

0.00023

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-1-[(4-propoxyphenyl)sulfonyl]pyrrolidin-2-yl]-carbonyl]hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00023 mM

652751

0.0018

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.0018 mM

652751

0.065

(3S,3aR,6aS)-1-(Cyclopropylcarbonyl)-4-([(2S)-1-[(3-isopropoxyphenyl)sulfonyl]pyrrolidin-2-yl]carbonyl)-3-methylhexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.065 mM

652734

0.00034

(3S,3aR,6aS)-1-(Cyclopropylcarbonyl)-4-[((2S)-1-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pyrrolidin-2-yl)carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.00034 mM

652734

0.00039

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-(4-isopropylbenzoyl)pyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)

Human betaherpesvirus 5

IC50: 0.00039 mM

652751

0.065

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[(3-isopropoxyphenyl)sulfonyl]pyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.065 mM

652751

0.0004

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[(4-isopropoxyphenyl)sulfonyl]pyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.0004 mM

652751

0.00046

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[(4-isopropylphenyl)sulfonyl]pyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00046 mM

652751

0.00034

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pyrrolidin-2-yl]-carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00034 mM

652751

0.0011

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[[6-(dimethylamino)-1-naphthyl]sulfonyl]pyrrolidin-2-yl]-carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.0011 mM

652751

0.014

(3S,3aR,6aS)-1-Acetyl-3-methyl-4-([(2S)-1-[(4-methylphenyl) sulfonyl]pyrrolidin-2-yl]carbonyl)hexahydropyrrolo-[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.014 mM

652734

0.00054

(3S,3aR,6aS)-1-Acetyl-4-[((2S)-1-[[5-(dimethylamino)-1-naphthyl] sulfonyl]pyrrolidin-2-yl)carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00054 mM

652734

0.05

(3S,3aR,6aS)-1-Acetyl-4-[[(2S)-1-benzoylpyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.05 mM

652734

0.0003

(3S,3aR,6aS)-4-[[(2S)-1-(1,1'-biphenyl-4-ylcarbonyl)-pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.0003 mM

652751

0.0014

(3S,3aR,6aS)-4-[[(2S)-1-(4-chlorobenzoyl)pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2-b]pyrrol-1(2H)-one

Human betaherpesvirus 5

IC50: 0.0014 mM

652751

0.0021

(3S,3aR,6aS)-4-[[(2S)-1-(benzylsulfonyl)pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.0021 mM

652751

0.00084

(3S,3aR,6aS)-4-[[(2S)-1-[(4-chlorophenyl)sulfonyl]pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00084 mM

652751

0.00019

(3S,3aR,6aS)-4-[[(2S)-1-[(5-chloro-3-methyl-1-benzothien-2-yl)carbonyl]pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: 0.00019 mM

652751

0.00014

3-[((2S)-2-[[(3aS,6S,6aR)-4-(Cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]pyrrolidin-1-yl)sulfonyl]-N,N-dimethylbenzamide

Human betaherpesvirus 5

IC50: 0.00014 mM

652734

0.0022

3-[[((2S)-2-[[(3aS,6S,6aR)-4-(Cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-carbonyl]pyrrolidin-1-yl)sulfonyl]methyl]-N,N-dimethylbenzamide

Human betaherpesvirus 5

IC50: 0.0022 mM

652734

0.013

4-(2-Etoxy-acetyl)-6-methyl-5-oxohexahydropyrrolo-[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.013 mM

652734

0.007

N-[(1S)-2-[rel-(3aS,6S,6aR)-4-(Cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-1-methyl-2-oxoethyl]-5-(dimethylamino)naphthalene-1-sulfonamide

Human betaherpesvirus 5

IC50: 0.007 mM

652734

0.001 - 0.367

N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide

4 entries

0.0037 - 0.094

N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide

4 entries

0.1

N-[2-[rel-(3aS,6S,6aR)-4-(Cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-2-oxoethyl]-5-(dimethylamino)-N-methylnaphthalene-1-sulfonamide

Human betaherpesvirus 5

IC50: above 0.1 mM

652734

0.805

rel-(3aS,6R,6aR)-4-acetoxyacetyl-6-methyl-5-oxohexahydro-pyrrolo[3,2-b]pyrrolo-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.805 mM

652724

1.8

rel-(3aS,6R,6aR)-4-acetyl-6-methyl-5-oxo-hexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 1.8 mM, 0.5 mM, 15.4% inhibition after 15 min

652724

0.5

rel-(3aS,6S,6aR)-4-(2,2-Dimethylpropanoyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.5

rel-(3aS,6S,6aR)-4-(2,4-Dinitrophenyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.5

rel-(3aS,6S,6aR)-4-(2-Hydroxy-3-phenoxypropyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.133

rel-(3aS,6S,6aR)-4-(3-Hydroxypropanoyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.133 mM

652734

0.5

rel-(3aS,6S,6aR)-4-(4-Methoxybenzoyl)-6-methyl-5-oxohexahydropyrrolo [3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.0115

rel-(3aS,6S,6aR)-4-(Bicyclo[4.2.0]octa-1,3,5-trien-7-ylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.0115 mM

652734

0.072

rel-(3aS,6S,6aR)-4-(cis-2,3-Dimethylcyclopropanecarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.072 mM

652734

0.032

rel-(3aS,6S,6aR)-4-(cyclobutylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.032 mM

652734

0.009

rel-(3aS,6S,6aR)-4-(Cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.009 mM

652734

0.5

rel-(3aS,6S,6aR)-4-(Dimethoxyphosphoryl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.5

rel-(3aS,6S,6aR)-4-(Hydroxymethyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.1

rel-(3aS,6S,6aR)-4-(trans-2,3-Dimethylcyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.1 mM

652734

0.398

rel-(3aS,6S,6aR)-4-Formyl-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.398 mM

652734

0.126

rel-(3aS,6S,6aR)-4-Isobutyryl-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.126 mM

652734

0.5

rel-(3aS,6S,6aR)-6-Methyl-4-(methylthio)-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.01

rel-(3aS,6S,6aR)-6-Methyl-4-[(2-methylcyclopropyl)-carbonyl]-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.01 mM

652734

0.25

rel-(3aS,6S,6aR)-6-Methyl-5-oxo-4-(1H-pyrrol-1-ylcarbonyl)-hexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: 0.25 mM

652734

0.5

rel-(3aS,6S,6aR)-6-Methyl-5-oxo-4-(2,2,3,3-tetramethylcyclopropylcarbonyl) hexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.5

rel-(3aS,6S,6aR)-6-Methyl-5-oxo-4-[(1E)-3-oxobut-1-enyl]-hexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Human betaherpesvirus 5

IC50: above 0.5 mM

652734

0.013

rel-(3S,3aR,6aS)-1-(Cyclopropylcarbonyl)-4-[(1-[[5-(dimethylamino)-1-naphthyl]sulfonyl]piperidin-2-yl)carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

IC50: above 0.013 mM

652734

0.079

rel-(3S,3aR,6aS)-1-Acetyl-3-methyl-4-(2-oxo-3-phenylpropyl) hexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.079 mM

652734

0.063

rel-(3S,3aR,6aS)-1-Acetyl-3-methyl-4-(phenoxyacetyl)-hexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.063 mM

652734

0.005

rel-(3S,3aR,6aS)-1-Acetyl-3-methyl-4-[(1-methyl-1Hpyrrol-2-yl)(oxo)acetyl]hexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.005 mM

652734

0.045

rel-(3S,3aR,6aS)-1-Acetyl-3-methyl-4-[(2-phenylethyl)-sulfonyl]hexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.045 mM

652734

0.006

rel-(3S,3aR,6aS)-1-Acetyl-4-[2-(5-fluoro-2-methyl-1Hindol-3-yl)acetyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

IC50: 0.006 mM

652734