3.4.21.97: assemblin

This is an abbreviated version!
For detailed information about assemblin, go to the full flat file.

Word Map on EC 3.4.21.97

3.4.21.97

viruses

genital

acyclovir

infectious

women

ganglia

transmitted

virion

thymidine

encephalitis

plaque

corneal

trigeminal

ocular

herpesviruses

keratitis

igg

herpetic

vaginal

seropositive

immunodeficiency

serological

immediate-early

type-1

ulcer

seroprevalence

type-specific

lytic

epstein-barr

chlamydia

tegument

neurotropic

cytopathic

oncolytic

syphilis

intravaginal

swab

postinfection

virus-specific

microbicide

replication-defective

seronegative

co-infection

ganciclovir

superinfect

pseudorabies

mucocutaneous

analysis

intercourse

medicine

heterosexual

cervicovaginal

Reaction

Cleaves -Ala-/-Ser- and -Ala-/-Ala- bonds in the scaffold protein =

Synonyms

Assemblin, assembly protein precursor-processing proteinase, capsid scaffolding protein, cytomegalovirus protease, cytomegalovius maturational protease, cytomeglovirus protease, HCMV protease, Herpes simplex virus 1 proteinase Pra, Herpes simplex virus endopeptidase, HHV-6 proteinase, hMCV, HSV 1 protease, HSV-1, HSV-1 protease, HSV-2, human cytomegalovirus maturational protease, human cytomegalovirus maturational proteinase, human cytomegalovirus protease, human cytomegalovirus proteinase, maturation proteinase, proteinase, assembly protein precursor-processing, pUL80a, SFA, Varicella-zoster virus gene 33 proteinase

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.97 assemblin

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Results	in table
3	Activating Compound
1132	AA Sequence
3	Application
1	CAS Registry Number
14	Cloned(Commentary)
16	Crystallization (Commentary)
1	General Information
1	General Stability
95	IC50 Value
120	Inhibitors
38	Ki Value [mM]
46	KM Value [mM]
8	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
72	Organism
38	PDB ID
6	pH Optimum
1	pH Range
2	pI Value
4	Posttranslational Modification
30	Protein Variants
8	Purification (Commentary)
2	Reaction
72	Reference
1	Source Tissue
4	Storage Stability
47	Substrates and Products (Substrate)
12	Subunits
49	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
44	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.97 - assemblin

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0.00001

(2S)-2-[[(3aS,6S,6aR)-4-(1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000041

(2S)-2-[[(3aS,6S,6aR)-4-(4-chloro-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000038

(2S)-2-[[(3aS,6S,6aR)-4-(4-methoxy-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000027

(2S)-2-[[(3aS,6S,6aR)-4-(5-chloro-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000022

(2S)-2-[[(3aS,6S,6aR)-4-(5-methoxy-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000117

(2S)-2-[[(3aS,6S,6aR)-4-(5-methoxy[1,3]thiazolo[5,4-b]-pyridin-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.0000074

(2S)-2-[[(3aS,6S,6aR)-4-(6-ethylcarboxylate-1,2-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]-pyrrol-1(2H)yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000017

(2S)-2-[[(3aS,6S,6aR)-4-(6-fluoro-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000043

(2S)-2-[[(3aS,6S,6aR)-4-(6-methoxy-1,3-benzothiazol-2-yl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000018

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-meth-yl5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropoxyphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000038

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-chlorophenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000002

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000009

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-propoxyphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000015

(2S)-2-[[(3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-[4-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000016

(2S)-2-[[(3aS,6S,6aR)-4-[(-cis-2,3-dimethylcyclopropyl)-cis-carbonyl]-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.00001

(2S)-2-[[(3aS,6S,6aR)-4-[5-[(difluoromethyl)sulfonyl]-1,3-benzothiazol-2-yl]-6-methyl-5-oxohexahydropyrrolo-[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)-pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.00004

(2S)-2-[[(3aS,6S,6aR)-4-[6-(hydroxymethyl)-1,3-benzothiazol-2-yl]-6-methyl-5-oxohexahydropyrrolo[3,2-b]-pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000025

(2S)-2-[[(3aS,6S,6aR)-6-methyl-4-(6-nitro-1,3-benzothiazol-2-yl)-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000446

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-(1,3-thiazol-2-yl)hexahydropyrrolo[3,2-b]pyrrol-1(2H)yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.000021

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-[1,3]thiazolo-[5,4-b]pyridin-2-ylhexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.00002

(2S)-2-[[(3aS,6S,6aR)-6-methyl-5-oxo-4-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl]-N-(4-isopropylphenyl)pyrrolidine-1-carboxamide

Human betaherpesvirus 5

-

-

0.00004

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-(2-naphthylsulfonyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.00006

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-1-(1-naphthylsulfonyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.000079

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-1-(4-propoxybenzoyl)pyrrolidin-2-yl]carbonyl]-hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.000033

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-3-methyl-4-[[(2S)-1-[(4-propoxyphenyl)sulfonyl]pyrrolidin-2-yl]-carbonyl]hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.00002

(3S,3aR,6aS)-1-(Cyclopropylcarbonyl)-4-[((2S)-1-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pyrrolidin-2-yl)carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2-one

Human betaherpesvirus 5

-

-

0.000039

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[(4-isopropoxyphenyl)sulfonyl]pyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.000099

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[(4-isopropylphenyl)sulfonyl]pyrrolidin-2-yl]carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.00002

(3S,3aR,6aS)-1-(cyclopropylcarbonyl)-4-[[(2S)-1-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pyrrolidin-2-yl]-carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.000034

(3S,3aR,6aS)-1-Acetyl-4-[((2S)-1-[[5-(dimethylamino)-1-naphthyl] sulfonyl]pyrrolidin-2-yl)carbonyl]-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.000021

(3S,3aR,6aS)-4-[[(2S)-1-(1,1'-biphenyl-4-ylcarbonyl)-pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

0.000002

(3S,3aR,6aS)-4-[[(2S)-1-[(5-chloro-3-methyl-1-benzothien-2-yl)carbonyl]pyrrolidin-2-yl]carbonyl]-1-(cyclopropylcarbonyl)-3-methylhexahydropyrrolo[3,2]pyrrol-2(1H)-one

Human betaherpesvirus 5

-

-

1.52

ac-VVNASC

Human betaherpesvirus 5

-

-

0.628

ac-VVNASCR

Human betaherpesvirus 5

-

-

0.39

ac-VVNASCRL

Human betaherpesvirus 5

-

-

0.072

GVVNAACRLA

Human betaherpesvirus 5

-

-

0.225

GVVNASCRLA

Human betaherpesvirus 5

-

-

0.699

VVNASCRL

Human betaherpesvirus 5

-

-

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Release 2023.1 (January 2023)