3.4.21.97: assemblin
This is an abbreviated version!
For detailed information about assemblin, go to the full flat file.
Word Map on EC 3.4.21.97
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3.4.21.97
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viruses
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genital
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acyclovir
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infectious
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women
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ganglia
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transmitted
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virion
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thymidine
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encephalitis
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plaque
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corneal
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trigeminal
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ocular
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herpesviruses
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keratitis
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igg
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herpetic
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vaginal
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seropositive
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immunodeficiency
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serological
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immediate-early
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type-1
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ulcer
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seroprevalence
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type-specific
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lytic
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epstein-barr
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chlamydia
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tegument
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neurotropic
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cytopathic
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oncolytic
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syphilis
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intravaginal
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swab
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postinfection
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virus-specific
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microbicide
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replication-defective
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seronegative
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co-infection
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ganciclovir
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superinfect
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pseudorabies
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mucocutaneous
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analysis
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intercourse
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medicine
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heterosexual
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cervicovaginal
- 3.4.21.97
- viruses
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genital
- acyclovir
- infectious
- women
- ganglia
- transmitted
- virion
- thymidine
- encephalitis
- plaque
- corneal
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trigeminal
-
ocular
- herpesviruses
- keratitis
- igg
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herpetic
- vaginal
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seropositive
- immunodeficiency
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serological
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immediate-early
- type-1
- ulcer
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seroprevalence
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type-specific
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lytic
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epstein-barr
- chlamydia
- tegument
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neurotropic
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cytopathic
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oncolytic
- syphilis
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intravaginal
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swab
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postinfection
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virus-specific
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microbicide
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replication-defective
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seronegative
- co-infection
- ganciclovir
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superinfect
- pseudorabies
-
mucocutaneous
- analysis
-
intercourse
- medicine
-
heterosexual
-
cervicovaginal
Reaction
Cleaves -Ala-/-Ser- and -Ala-/-Ala- bonds in the scaffold protein =
Synonyms
Assemblin, assembly protein precursor-processing proteinase, capsid scaffolding protein, cytomegalovirus protease, cytomegalovius maturational protease, cytomeglovirus protease, HCMV protease, Herpes simplex virus 1 proteinase Pra, Herpes simplex virus endopeptidase, HHV-6 proteinase, hMCV, HSV 1 protease, HSV-1, HSV-1 protease, HSV-2, human cytomegalovirus maturational protease, human cytomegalovirus maturational proteinase, human cytomegalovirus protease, human cytomegalovirus proteinase, maturation proteinase, proteinase, assembly protein precursor-processing, pUL80a, SFA, Varicella-zoster virus gene 33 proteinase
ECTree
3.4.21.97 assemblinAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.21.97 - assemblin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNAS-2-aminobutanoyl-RLN-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid + H2O
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNA + S-2-aminobutanoyl-RLN-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid
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-
-
?
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNAS-2-aminobutanoyl-RLN-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid + H2O
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNA + Ser-2-aminobutanoyl-RLN-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid
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-
-
-
?
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNAS-2-aminobutanoyl-RLN-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid + H2O
?
-
-
-
-
?
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNASSRLA-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid + H2O
4-(4'-dimethylaminophenazo)benzoic acid-RGVVNA + SSRLA-5-[(2'-aminoethyl)-amino]-naphthalene-1-sulfonic acid
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-
-
?
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-Ala((2'-aminoethyl)amino-naphthalene-1)sulfonic acid + H2O
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala + Ser-Ser-Arg-Leu-Ala((2'-aminoethyl)amino-naphthalene-1)sulfonic acid
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-
-
?
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-Ala-5-((2'-aminoethyl)amino)-naphthalene-1-sulfonic acid + H2O
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala + Ser-Ser-Arg-Leu-Ala-5-((2'-aminoethyl)amino)-naphthalene-1-sulfonic acid
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Arg-Gly-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-Ala-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Arg-Gly-Val-Val-Asn-Ala + Ser-Ser-Arg-Leu-Ala-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid
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-
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?
Abz-GVVNASSRLAY(NO2)G + H2O
anthranilamide-GVVNA + SSRLAY(NO2)G
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-
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?
Abz-VVNASSLY(3-NO2)R-OH + H2O
Abz-VVNA + SSLY(3-NO2)R-OH
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-
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?
acetyl-Cys-tert-butylglycine-tert-butylglycine-Asn(Me)2-Ala-7-amido-4-methylcoumarin + H2O
acetyl-Cys-tert-butylglycine-tert-butylglycine-Asn(Me)2-Ala + 7-amino-4-methylcoumarin
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-
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?
acetyl-L-Gln-L-Ala-gancyclovir + H2O
acetyl-L-Gln-L-Ala + ganciclovir
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dipeptide prodrugs of ganciclovir
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-
?
assembly protein precursor of cytomegalovirus + H2O
?
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the enzyme is essential for virus replication and functions during capsid assembly from pAP, i.e. assembly protein precursor
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-
?
biotinyl-RGVVNASSRLAK-fluorescein isothiocyanate + H2O
biotinyl-RGVVNA + SSRLAK-fluorescein isothiocyanate
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-
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?
cytomegalovirus assembly protein precursor + H2O
?
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cleavage at the C-terminal maturation site, i.e. M-site, between Ala643-Ser644, autoproteolytic cleavage at the R-site between Ala256-Ser257, internal cleavage sites, i.e. I-sites are Ala143-Ala144, Ala209-Ser210, cleavage occurs at the M-site first, followed by the R-site and then the I-sites
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-
?
N-(5'-phosphoribosyl)anthranilate isomerase + H2O
?
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site-specific cleavage and functional inactivation of the N-(5'-phosphoribosyl)anthranilate isomerase, thereby leading to an arrest of cell proliferation. Coexpressing N-(5'-phosphoribosyl)anthranilate isomerase1194-M with the protease exhibits a growth reduction of 35%. N-(5'-phosphoribosyl)anthranilate isomerase1132-M- as well as N-(5'-phosphoribosyl)anthranilate isomerase1165-M-expressing cells do not show growth reduction upon coexpressing HCMV protease, thus no cleavage occurs. Cells expressing the modified N-(5'-phosphoribosyl)anthranilate isomerase1194-Me together with the active protease show 85% reduction of cell proliferation, is cleaved in a sequence-specific manner
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?
pPR + H2O
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one substrate used in this study is pPR itself inactivated by replacing its catalytic nucleophile (S132A)
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-
?
simian cytomegalovirus precursor assembly protein + H2O
assembly protein
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assemblin and its precursor, pPR, have comparable enzymatic activities
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-
?
succinyl-LVNAS-2-aminobutyryl-Arg-NH2 + H2O
succinyl-LVNA + Ser-2-aminobutyryl-Arg-NH2
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-
-
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?
succinyl-LVNAS-2-aminobutyryl-EPT-NH2
succinyl-LVNA + S-2-aminobutyryl-EPT-NH2
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-
-
?
succinyl-LVNAS-2-aminobutyryl-EPT-NH2 + H2O
succinyl-LVNA + Ser-2-aminobutyryl-EPT-NH2 + H2O
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-
-
-
?
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-Ala-5-((2'-aminoethyl)amino)-naphthalene-1-sulfonic acid + H2O
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala + Ser-Ser-Arg-Leu-Ala-5-((2'-aminoethyl)amino)-naphthalene-1-sulfonic acid
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-
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?
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-Ala-5-((2'-aminoethyl)amino)-naphthalene-1-sulfonic acid + H2O
4-(4'-dimethylaminophenylazo)benzoyl-Arg-Gly-Val-Val-Asn-Ala + Ser-Ser-Arg-Leu-Ala-5-((2'-aminoethyl)amino)-naphthalene-1-sulfonic acid
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studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology
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-
?
RGVVNASSRLAK + H2O
RGVVNA + SSRLAK
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substrate mimicking M-site substrate
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?
succinyl-RRYIKASEPPV-NH2 + H2O
succinyl-RRYIKA + SEPPV-NH2
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-
-
?
succinyl-VVNAS-2-aminobutyryl-R-NH2 + H2O
succinyl-VVNA + S-2-aminobutyryl-R-NH2
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-
-
-
?
succinyl-VVNAS-2-aminobutyryl-R-NH2 + H2O
succinyl-VVNA + S-2-aminobutyryl-R-NH2
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-
-
?
SYVKASVSPE + H2O
SYVKA + SVSPE
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substrate mimicking R-site substrate
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?
additional information
?
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the production of infectious cytomegalovirus requires neither I-site cleavage of assemblin nor the presence of assemblin in mature virion
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?
