3.4.21.86: Limulus clotting enzyme
This is an abbreviated version!
For detailed information about Limulus clotting enzyme, go to the full flat file.
Word Map on EC 3.4.21.86
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3.4.21.86
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thrombin
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horseshoe
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crab
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tachypleus
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tridentatus
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amebocyte
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coagulogens
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proclotting
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prothrombinase
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coagulin
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phenol-water
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rennet
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molecular biology
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analysis
- 3.4.21.86
- thrombin
-
horseshoe
- crab
- tachypleus
- tridentatus
-
amebocyte
- coagulogens
-
proclotting
- prothrombinase
- coagulin
-
phenol-water
-
rennet
- molecular biology
- analysis
Reaction
Selective cleavage of -Arg18-/- and -Arg47-/- bonds in coagulogen to form coagulin and fragments =
Synonyms
Clotting enzyme, Limulus clotting enzyme
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 3.4.21.86 - Limulus clotting enzyme
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glycoprotein
proteolytic modification
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3 potential glycosylation sites for N-linked carbohydrate chains. Moreover the zymogen contains 6 O-linked carbohydrate chains in the amino-terminal light chain generated after activation
glycoprotein
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11% carbohydrate content, contains 11 and 10 residues of glucosamine and galactosamine, resp
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the pro-clotting enzyme is activated by cleavage through factor B or factor G, the latter with less activity
proteolytic modification
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inactive proenzyme of 54 kDa is converted to its active form of 25 kDa + 31 kDa by purified factor B or by trypsin. Heavy and light chain of active form are bridged by a disulfide linkage