3.4.21.86: Limulus clotting enzyme

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For detailed information about Limulus clotting enzyme, go to the full flat file.

Reaction

Selective cleavage of -Arg18-/- and -Arg47-/- bonds in coagulogen to form coagulin and fragments =

Synonyms

Clotting enzyme, Limulus clotting enzyme

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.86 Limulus clotting enzyme

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General Information

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General Information on EC 3.4.21.86 - Limulus clotting enzyme

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Limulus polyphemus

-

the enzyme is part of the clotting cascade of Limulus polyphemus. Factor C, the first component of the cascade, is a serine protease that is activated by endotoxin binding. The cascade, initiated by lipopolysaccharide, culminates in the activation of the pro-clotting enzyme to its active form, the clotting enzyme, which in turn acts on coagulogen to convert it into the coagulin clot

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