3.4.21.32: brachyurin

This is an abbreviated version!
For detailed information about brachyurin, go to the full flat file.

Reaction

hydrolysis of proteins, with broad specificity for peptide bonds. Native collagen is cleaved about 75% of the length of the molecule from the N-terminus. Low activity on small molecule substrates of both trypsin and chymotrypsin =

Synonyms

aspergillopeptidase C, azocollase, clostridiopeptidase A, clostridiopeptidase I, clostridiopeptidase II, CLSP, collagen peptidase, collagenase, collagenase A, collagenase MMP-1, collagenolytic protease, collagenolytic serine protease, crab protease I, crab protease II, Es-CLSP, kollaza, matrix metalloproteinase-1, matrix metalloproteinase-18, Matrix metalloproteinase-8, metallocollagenase, metalloproteinase-1, MMP-1, MMP-8, non-clip domain serine protease, nucleolysin, peptidase, clostridio-, A, protease PC, proteinase, Clostridium histolyticum, A, PtSP, PtSPH1, soycollagestin, Try4, uca pugilator collagenolytic proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.32 brachyurin

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Results	in table
23	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
1	Crystallization (Commentary)
3	Expression
4	General Information
39	Inhibitors
8	KM Value [mM]
8	Metals/Ions
9	Molecular Weight [Da]
22	Organism
2	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
1	pI Value
3	Posttranslational Modification
8	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
32	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
33	Substrates and Products (Substrate)
7	Subunits
37	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.4.21.32 - brachyurin

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Collagen + H2O

Hydrolyzed collagen

9 entries

N-acetyl-L-Ala-L-Ala-L-Ala-p-nitroanilide + H2O

?

Leptuca pugilator

-

-

36545, 36546

-

-

?

N-benzoyl-L-Arg-p-nitroanilide + H2O

?

3 entries

N-benzoyl-L-Tyr ethyl ester + H2O

?

2 entries

N-benzoyl-L-Tyr-p-nitroanilide + H2O

?

Leptuca pugilator

-

-

36545, 36546

-

-

?

N-benzoyl-L-Val-Gly-L-Arg-p-nitroanilide + H2O

?

2 entries

Nalpha-tosyl-L-Arg methyl ester + H2O

?

Leptuca pugilator

-

-

36545, 36546

-

-

?

succinyl-Ala-p-nitroanilide + H2O

?

Carcinus maenas

-

-

36551

-

-

?

succinyl-L-Ala-L-Ala-L-Pro-L-Leu-p-nitroanilide + H2O

?

2 entries

succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroanilide + H2O

?

2 entries

additional information

?

-

Leptuca pugilator

-

substrate succinyl-Ala-Ala-Pro-Xaa-p-nitroanilide for testing substrate specificity

36554

-

-

?

Collagen + H2O

Hydrolyzed collagen

Carcinus maenas

-

type I and III

36551

-

-

?

Collagen + H2O

Hydrolyzed collagen

Gadus morhua

-

type I,III, IV and V

36550

-

-

?

Collagen + H2O

Hydrolyzed collagen

Leptuca pugilator

-

-

36545, 36554

-

-

?

Collagen + H2O

Hydrolyzed collagen

Leptuca pugilator

-

type I

36544

-

-

?

Collagen + H2O

Hydrolyzed collagen

Leptuca pugilator

-

cleaves bovine collagen I chain C-terminal to Gln and Arg residues adjacent to the metallocollagenase site

36553

-

-

?

Collagen + H2O

Hydrolyzed collagen

Novoden modestrus

-

-

651826

-

651826

?

Collagen + H2O

Hydrolyzed collagen

Paralithodes camtschaticus

-

-

36556

-

-

?

Collagen + H2O

Hydrolyzed collagen

Paralithodes camtschaticus

-

calf skin collagen type III and bovine lens capsule collagen type IV

36555

-

-

?

Collagen + H2O

Hydrolyzed collagen

Penaeus monodon

-

collagen type I

36557

-

-

?

N-benzoyl-L-Arg-p-nitroanilide + H2O

?

Leptuca pugilator

-

-

36545, 36546

-

-

?

N-benzoyl-L-Arg-p-nitroanilide + H2O

?

Paralithodes camtschaticus

-

-

36556

-

-

?

N-benzoyl-L-Arg-p-nitroanilide + H2O

?

Penaeus monodon

-

-

36557

-

-

?

N-benzoyl-L-Tyr ethyl ester + H2O

?

Leptuca pugilator

-

-

36545, 36546, 36548

-

-

?

N-benzoyl-L-Tyr ethyl ester + H2O

?

Paralithodes camtschaticus

-

-

36556

-

-

?

N-benzoyl-L-Val-Gly-L-Arg-p-nitroanilide + H2O

?

Leptuca pugilator

-

-

36545, 36546

-

-

?

N-benzoyl-L-Val-Gly-L-Arg-p-nitroanilide + H2O

?

Penaeus monodon

-

-

36557

-

-

?

succinyl-L-Ala-L-Ala-L-Pro-L-Leu-p-nitroanilide + H2O

?

Carcinus maenas

-

-

36551

-

-

?

succinyl-L-Ala-L-Ala-L-Pro-L-Leu-p-nitroanilide + H2O

?

Gadus morhua

-

-

36550

-

-

?

succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroanilide + H2O

?

Carcinus maenas

-

-

36551

-

-

?

succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroanilide + H2O

?

Gadus morhua

-

-

36550

-

-

?