3.4.17.15: carboxypeptidase A2
This is an abbreviated version!
For detailed information about carboxypeptidase A2, go to the full flat file.
Word Map on EC 3.4.17.15
Reaction
Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues =
Synonyms
ADA2, carboxypeptidase-A2, CP-A2, CPA2
ECTree
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Substrates Products on EC 3.4.17.15 - carboxypeptidase A2
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
angiotensin-(1-12) + H2O
angiotensin I + ?
-
-
conversion of Ang-(1-12) to Ang I proceeds through stepwise cleavage of C-terminal Tyr and Leu residues
-
?
hippuryl-DL-phenyllactate + H2O
hippuric acid + DL-phenyllactate
-
preferred substrate
-
-
?
methotrexate-alpha-(1-naphthyl)alanine + H2O
methotrexate + (1-naphthyl)alanine
-
-
-
-
?
additional information
?
-
-
no measurable activity with benzyloxycarbonyl-Gly-Gly-Val, benzyloxycarbonyl-Gly-Gly-Ala und benzyloxycarbonyl-Gly-Gly-Ser. CPA2 is the only reported carboxypeptidase with specificity for C-terminal Trp residues
-
-
?
additional information
?
-
-
the enzyme is not involved in development of Silver-Russell syndrome disease
-
-
?
additional information
?
-
-
carboxy-terminal amino acids with aromatic or branched aliphatic side chains are preferred
-
-
?
