3.4.11.15: aminopeptidase Y

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For detailed information about aminopeptidase Y, go to the full flat file.

Reaction

preferentially, release of N-terminal lysine =

Synonyms

AAP, aminopeptidase (cobalt-activated), aminopeptidase Co, APE3, LapB, lysine aminopeptidase, PF1861, PH1821, PhTET3, TET3, yylAPE

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.15 aminopeptidase Y

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Results	in table
3	Activating Compound
256	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
1	General Information
2	General Stability
1	IC50 Value
48	Inhibitors
5	kcat/KM [mM/s]
7	KM Value [mM]
8	Localization
17	Metals/Ions
14	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
18	Organism
3	PDB ID
9	pH Optimum
2	pH Range
1	pH Stability
1	pI Value
5	Posttranslational Modification
1	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
18	Reference
6	Specific Activity [micromol/min/mg]
65	Substrates and Products (Substrate)
10	Subunits
15	Synonyms
6	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
5	Turnover Number [1/s]

General Information

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General Information on EC 3.4.11.15 - aminopeptidase Y

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Saccharomyces cerevisiae

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lysosomes isolated from APE3 overexpressing cells exhibit better antimicrobial effects than normal cells, and anticancerous effects of lysosomes isolated from the overexpressing Saccharomyces cerevisiae increase on cancer cells such as HeLa, HaCaT, and melanoma cells by in vitro assay

754721