3.4.11.15: aminopeptidase Y
This is an abbreviated version!
For detailed information about aminopeptidase Y, go to the full flat file.
Word Map on EC 3.4.11.15
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3.4.11.15
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carboxypeptidase
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pyrococcus
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aminopeptidases
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horikoshii
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bestatin
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p-nitroanilide
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griseus
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lys-pna
- 3.4.11.15
- carboxypeptidase
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pyrococcus
- aminopeptidases
- horikoshii
- bestatin
- p-nitroanilide
- griseus
-
lys-pna
Reaction
preferentially, release of N-terminal lysine =
Synonyms
AAP, aminopeptidase (cobalt-activated), aminopeptidase Co, APE3, LapB, lysine aminopeptidase, PF1861, PH1821, PhTET3, TET3, yylAPE
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Inhibitors on EC 3.4.11.15 - aminopeptidase Y
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
Co2+
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25fold enhancement of hydrolysis of Arg-7-amido-4-methylcoumarin and Lys-7-amido-4-methylcoumarin. Hydrolysis of substrates longer than tripeptide or dipeptide-7-amido-4-methylcoumarin is inhibited, IC50: 0.1 mM
additional information
the enzyme is insensitive to the papain and trypsin inhibitor antipain, to the cysteine proteases inhibitor E-64, to the serine and cysteine proteases inhibitor leupeptin, to the aspartate proteases inhibitor pepstatin, and to the metalloendopeptidases inhibitor phosphoramidon. Puromycin, an inhibitor of some exopeptidases, has practically no effect on the activity of PhTET3
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additional information
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the enzyme is insensitive to the papain and trypsin inhibitor antipain, to the cysteine proteases inhibitor E-64, to the serine and cysteine proteases inhibitor leupeptin, to the aspartate proteases inhibitor pepstatin, and to the metalloendopeptidases inhibitor phosphoramidon. Puromycin, an inhibitor of some exopeptidases, has practically no effect on the activity of PhTET3
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