3.2.1.129: endo-alpha-sialidase

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For detailed information about endo-alpha-sialidase, go to the full flat file.

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Synonyms

alpha-2,8-sialosylhydrolase, endo-N, endo-N 1588, endo-N-acetylneuraminidase, endo-sialidase, endoE, EndoN Trap, endoN92, endoneuraminidase, endoneuraminidase-N, endoNF, EndoNt, endosialidase, endosialidase E, endosialidase NF, endosialidaseNF, G102, gp47, neuraminidase, endo-, poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase, poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase, poly(sialoside) alpha-2,8-sialosylhydrolase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.129 endo-alpha-sialidase

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Results	in table
21	AA Sequence
12	Application
1	CAS Registry Number
14	Cloned(Commentary)
5	Crystallization (Commentary)
34	Disease/ Diagnostics
4	General Information
1	Inhibitors
15	KM Value [mM]
13	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
34	Organism
27	PDB ID
2	pH Optimum
1	Posttranslational Modification
56	Protein Variants
14	Purification (Commentary)
1	Reaction
6	Reaction Type
34	Reference
10	Source Tissue
9	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
11	Subunits
55	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

Disease

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Disease on EC 3.2.1.129 - endo-alpha-sialidase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Unique alpha 2, 8-polysialylated glycoproteins in breast cancer and leukemia cells.

8724137

Dehydration

Cell surface expression of polysialic acid on NCAM is a prerequisite for activity-dependent morphological neuronal and glial plasticity.

10575020

Fasciculation

Analysis of high PSA N-CAM expression during mammalian spinal cord and peripheral nervous system development.

1769342

Fasciculation

Polysialic acid as a regulator of intramuscular nerve branching during embryonic development.

2344405

Infections

Administration of Capsule-Selective Endosialidase E Minimises Up-Regulation of Organ Gene Expression Induced by Experimental Systemic Infection with Escherichia coli K1.

20395269

Infections

Treatment of experimental Escherichia coli infection with recombinant bacteriophage-derived capsule depolymerase.

15914489

Leukemia

Unique alpha 2, 8-polysialylated glycoproteins in breast cancer and leukemia cells.

8724137

Neoplasm Metastasis

A nude mice model of human rhabdomyosarcoma lung metastases for evaluating the role of polysialic acids in the metastatic process.

11314035

Neoplasms

A nude mice model of human rhabdomyosarcoma lung metastases for evaluating the role of polysialic acids in the metastatic process.

11314035

Neoplasms

Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids.

1651057

Neoplasms

Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion.

12744370

Seizures

PSA-NCAM-dependent GDNF signaling limits neurodegeneration and epileptogenesis in temporal lobe epilepsy.

20597970

Seizures

Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development.

18194217

Sleep Deprivation

Role of polysialylated neural cell adhesion molecule in rapid eye movement sleep regulation in rats.

20128854

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