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3.2.1.129: endo-alpha-sialidase

This is an abbreviated version!
For detailed information about endo-alpha-sialidase, go to the full flat file.

Word Map on EC 3.2.1.129

Reaction

sialyl-alpha(2-8)sialyl-alpha(2-8)sialyl-alpha(2-8)sialic acid
+
H2O
= 2 sialyl-alpha(2-8)sialic acid

Synonyms

alpha-2,8-sialosylhydrolase, endo-N, endo-N 1588, endo-N-acetylneuraminidase, endo-sialidase, endoE, EndoN Trap, endoN92, endoneuraminidase, endoneuraminidase-N, endoNF, EndoNt, endosialidase, endosialidase E, endosialidase NF, endosialidaseNF, G102, gp47, neuraminidase, endo-, poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase, poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase, poly(sialoside) alpha-2,8-sialosylhydrolase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.129 endo-alpha-sialidase

Reference

Reference on EC 3.2.1.129 - endo-alpha-sialidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kitajima, K.; Inoue, S.; Inoue, Y.; Troy, F.A.
Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies
J. Biol. Chem.
263
18269-18276
1988
Escherichia phage K1F
Manually annotated by BRENDA team
Pelkonen, S.; Pelkonen, J.; Finne, J.
Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins
J. Virol.
63
4409-4416
1989
bacteriophage PK1A, bacteriophage PK1E
Manually annotated by BRENDA team
Kwiatowski, B.; Boschek, B.; Thiele, H.; Stirm, S.
endo-N-Acetylneuraminidase associated with bacteriophage particles
J. Virol.
43
697-704
1982
bacteriophage phi1.2
Manually annotated by BRENDA team
Finne, J.; Mäkelä, P.H.
Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid
J. Biol. Chem.
260
1265-1270
1985
bacteriophage PK1A
Manually annotated by BRENDA team
Tomlinson, S.; Taylor, P.W.
Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide
J. Virol.
55
374-378
1985
Phage E
Manually annotated by BRENDA team
Hallenbeck, P.C.; Vimr, E.R.; Yu, F.; Bassler, B.; Troy, F.A.
Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units
J. Biol. Chem.
262
3553-3561
1987
Escherichia phage K1F
Manually annotated by BRENDA team
Vimr, E.R.; McCoy, R.D.; Vollger, H.F.; Wilkinson, N.C.; Troy, F.A.
Use of prokaryotic-derived probes to identify poly(sialic acid) in neonatal neuronal membranes
Proc. Natl. Acad. Sci. USA
81
1971-1975
1984
Escherichia phage K1F
Manually annotated by BRENDA team
Muhlenhoff, M.; Stummeyer, K.; Grove, M.; Sauerborn, M.; Gerardy-Schahn, R.
Proteolytic processing and oligomerization of bacteriophage-derived endosialidases
J. Biol. Chem.
278
12634-12644
2003
Escherichia phage K1F, Vectrevirus K1E
Manually annotated by BRENDA team
Long, G.S.; Bryant, J.M.; Taylor, P.W.; Luzio, J.P.
Complete nucleotide sequence of the gene encoding bacteriophage E endosialidase: implications for K1E endosialidase structure and function
Biochem. J.
309
543-550
1995
Vectrevirus K1E
Manually annotated by BRENDA team
Leggate, D.R.; Bryant, J.M.; Redpath, M.B.; Head, D.; Taylor, P.W.; Luzio, J.P.
Expression, mutagenesis and kinetic analysis of recombinant K1E endosialidase to define the site of proteolytic processing and requirements for catalysis
Mol. Microbiol.
44
749-760
2002
Vectrevirus K1E
Manually annotated by BRENDA team
Gerardy-Schahn, R.; Bethe, A.; Brennecke, T.; Muhlenhoff, M.; Eckhardt, M.; Ziesing, S.; Lottspeich, F.; Frosch, M.
Molecular cloning and functional expression of bacteriophage PK1E-encoded endoneuraminidase Endo NE
Mol. Microbiol.
16
441-450
1995
bacteriophage PK1E
Manually annotated by BRENDA team
Stummeyer, K.; Dickmanns, A.; Mühlenhoff, M.; Gerardy-Schahn, R.; Ficner, R.
Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F
Nat. Struct. Mol. Biol.
12
90-96
2005
Escherichia phage K1F (Q04830), Escherichia phage K1F
Manually annotated by BRENDA team
Jakobsson, E.; Jokilammi, A.; Aalto, J.; Ollikka, P.; Lehtonen, J.V.; Hirvonen, H.; Finne, J.
Identification of amino acid residues at the active site of endosialidase that dissociate the polysialic acid binding and cleaving activities in Escherichia coli K1 bacteriophages
Biochem. J.
405
465-472
2007
Vectrevirus K1E, Enterobacteria phage K1A (A4UUQ0)
Manually annotated by BRENDA team
Haselhorst, T.; Stummeyer, K.; Muhlenhoff, M.; Schaper, W.; Gerardy-Schahn, R.; von Itzstein, M.
Endosialidase NF appears to bind polySia DP5 in a helical conformation
Chembiochem
7
1875-1877
2006
Bacteriophage sp.
Manually annotated by BRENDA team
Schwarzer, D.; Stummeyer, K.; Gerardy-Schahn, R.; Muehlenhoff, M.
Characterization of a Novel Intramolecular Chaperone Domain Conserved in Endosialidases and Other Bacteriophage Tail Spike and Fiber Proteins
J. Biol. Chem.
282
2821-2831
2007
Escherichia phage K1F
Manually annotated by BRENDA team
Berski, S.; van Bergeijk, J.; Schwarzer, D.; Stark, Y.; Kasper, C.; Scheper, T.; Grothe, C.; Gerardy-Schahn, R.; Kirschning, A.; Draeger, G.
Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering
Biomacromolecules
9
2353-2359
2008
Escherichia phage K1F
Manually annotated by BRENDA team
Haile, Y.; Berski, S.; Draeger, G.; Nobre, A.; Stummeyer, K.; Gerardy-Schahn, R.; Grothe, C.
The effect of modified polysialic acid based hydrogels on the adhesion and viability of primary neurons and glial cells
Biomaterials
29
1880-1891
2008
Escherichia phage K1F
Manually annotated by BRENDA team
Murphy, J.A.; Hartwick, A.T.; Rutishauser, U.; Clarke, D.B.
Endogenous polysialylated neural cell adhesion molecule enhances the survival of retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.
50
861-869
2009
Escherichia phage K1F
Manually annotated by BRENDA team
Schwarzer, D.; Stummeyer, K.; Haselhorst, T.; Freiberger, F.; Rode, B.; Grove, M.; Scheper, T.; von Itzstein, M.; Muehlenhoff, M.; Gerardy-Schahn, R.
Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase f
J. Biol. Chem.
284
9465-9474
2009
Escherichia phage K1F
Manually annotated by BRENDA team
Pekcec, A.; Fuest, C.; Muehlenhoff, M.; Gerardy-Schahn, R.; Potschka, H.
Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development
J. Neurochem.
105
389-400
2008
Escherichia phage K1F
Manually annotated by BRENDA team
Schulz, E.C.; Neumann, P.; Gerardy-Schahn, R.; Sheldrick, G.M.; Ficner,R.
Structure analysis of endosialidase NF at 0.98 A resolution
Acta Crystallogr. Sect. D
66
176-180
2010
Escherichia phage K1F
Manually annotated by BRENDA team
Morley, T.J.; Willis, L.M.; Whitfield, C.; Wakarchuk, W.W.; Withers, S.G.
A new sialidase mechanism: bacteriophage K1F endo-sialidase is an inverting glycosidase
J. Biol. Chem.
284
17404-17410
2009
Escherichia phage K1F
Manually annotated by BRENDA team
Schulz, E.C.; Schwarzer, D.; Frank, M.; Stummeyer, K.; Muehlenhoff, M.; Dickmanns, A.; Gerardy-Schahn, R.; Ficner, R.
Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein endoNF
J. Mol. Biol.
397
341-351
2010
Escherichia phage K1F (Q04830)
Manually annotated by BRENDA team
Zelmer, A.; Martin, M.J.; Gundogdu, O.; Birchenough, G.; Lever, R.; Wren, B.W.; Luzio, J.P.; Taylor, P.W.
Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1
Microbiology
156
2205-2215
2010
Escherichia coli, Escherichia coli A192PP
Manually annotated by BRENDA team
Chai, Y.; Xiong, H.; Ma, X.; Cheng, L.; Huang, G.; Zhang, Z.R.
Molecular characterization, structural analysis and determination of host range of a novel bacteriophage LSB-1
Virol. J.
7
255
2010
Phage LSB-1
Manually annotated by BRENDA team
Schwarzer, D.; Browning, C.; Stummeyer, K.; Oberbeck, A.; Muehlenhoff, M.; Gerardy-Schahn, R.; Leiman, P.G.
Structure and biochemical characterization of bacteriophage phi92 endosialidase
Virology
477
133-143
2015
Enterobacteria phage phi92 (I7HXG2)
Manually annotated by BRENDA team
Hsu, H.J.; Palka-Hamblin, H.; Bhide, G.P.; Myung, J.H.; Cheong, M.; Colley, K.J.; Hong, S.
Noncatalytic endosialidase enables surface capture of small-cell lung cancer cells utilizing strong dendrimer-mediated enzyme-glycoprotein interactions
Anal. Chem.
90
3670-3675
2018
Homo sapiens
Manually annotated by BRENDA team
Martin, N.T.; Wrede, C.; Niemann, J.; Brooks, J.; Schwarzer, D.; Kuehnel, F.; Gerardy-Schahn, R.
Targeting polysialic acid-abundant cancers using oncolytic adenoviruses with fibers fused to active bacteriophage borne endosialidase
Biomaterials
158
86-94
2018
Escherichia phage K1F (O04830), Escherichia phage K1F
Manually annotated by BRENDA team
Li, C.; Zhang, Y.X.; Yang, C.; Hao, F.; Chen, S.S.; Hao, Q.; Lu, T.; Qu, T.Y.; Zhao, L.R.; Duan, W.M.
Intraventricular administration of endoneuraminidase-N facilitates ectopic migration of subventricular zone-derived neural progenitor cells into 6-OHDA lesioned striatum of mice
Exp. Neurol.
277
139-149
2016
Mus musculus
Manually annotated by BRENDA team
Gebhart, D.; Williams, S.R.; Scholl, D.
Bacteriophage SP6 encodes a second tailspike protein that recognizes Salmonella enterica serogroups C2 and C3
Virology
507
263-266
2017
Zindervirus SP6
Manually annotated by BRENDA team