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3.2.1.108: lactase

This is an abbreviated version!
For detailed information about lactase, go to the full flat file.

Word Map on EC 3.2.1.108

Reaction

lactose
+
H2O
=
D-galactose
 +
D-glucose

Synonyms

intestinal lactase, lactase, lactase phlorizin hydrolase, lactase phlorizin-hydrolase, lactase-phlorizin hydrolase, lactase-phlorizin hydrolase LPH, lactase-phlorozin hydrolase, lactase/phlorizin hydrolase, LCT, LPH

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.108 lactase

Engineering

Engineering on EC 3.2.1.108 - lactase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D1711N
-
introduction of potential N-glycosilation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency
E1612X
results in congenital lactase deficiency
G1363S
I1697N
-
introduction of potential N-glycosilation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency
more |
-
CC13910, lactose intolerance, low lactase genotype, no predispose for cataracts with mutation of galactose-1-phosphate uridyl transferase
P1743S
-
introduction of potential N-glycosilation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency
Q268H
-
congential lactase deficiency, CLD, mutation, DNA mutation c.804G->C, genotype compound heterozygote for Y1390X
R1587H
results in congenital lactase deficiency
S1666fsX1722
-
congential lactase deficiency, CLD, mutation, DNA mutation c.4998_5001delTGAG, genotype compound heterozygote for Y1390X
S218fsX224
-
congential lactase deficiency, CLD, mutation, DNA mutation c.653_654delCT, genotype compound heterozygote for Y1390X
S688P
results in congenital lactase deficiency
Y1390X
up
thyroid and glucocorticoid hormones synergistically enhance expression of the LPH gene in CDX-2/HNF-1alphaa co-transfected IEC-6 cells
additional information