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2-O-beta-D-galactopyranosyl-D-xylose + H2O
D-galactose + D-xylose
-
-
-
-
?
3-O-beta-D-galactopyranosyl-D-xylose + H2O
D-galactose + D-xylose
-
-
-
-
?
4-O-beta-D-galactopyranosyl-D-xylose + H2O
D-galactose + D-xylose
-
-
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-fucopyranoside + H2O
?
-
37°C, 1 hour, full-length lactase, mature lactase, cytosolic form of mature lactase
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside + H2O
?
baohuoside I + H2O
? + D-glucose
cellobiose + H2O
2 beta-D-glucose
cellotetraose + 3 H2O
4 beta-D-glucose
cellotriose + H2O
3 D-glucose
cellulose + H2O
beta-D-glucose
daidzein 7-O-beta-D-glucopyranoside + H2O
daidzein + beta-D-glucose
epimedin A + H2O
? + D-glucose
epimedin B + H2O
? + D-glucose
epimedin C + H2O
? + D-glucose
fluorescein-di-beta-D-galactopyranoside + H2O
?
-
only cytosolic form of mature lactase
-
-
?
genistein-7-glucoside + H2O
genistein + D-glucose
-
-
-
-
?
gentiobiose + H2O
2 beta-D-glucose
-
0.7% of the activity with lactose
-
-
?
icariin + H2O
? + D-glucose
lactose + H2O
D-galactose + D-glucose
lactose + H2O
D-glucose + D-galactose
lactose + H2O
galactose + D-glucose
-
reaction is not inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
methyl-beta-D-glucoside + H2O
methanol + beta-D-glucose
-
7.3% of the activity with lactose
-
-
?
o-nitrophenyl-beta-galactoside + H2O
o-nitrophenol + beta-D-galactose
o-nitrophenyl-beta-glucoside + H2O
o-nitrophenol + beta-D-glucose
-
13% of the activity with lactose
-
-
?
p-nitrophenyl-beta-galactoside + H2O
p-nitrophenol + beta-D-galactose
p-nitrophenyl-beta-glucoside + H2O
p-nitrophenol + beta-D-glucose
phenyl-beta-galactoside + H2O
phenol + beta-D-galactose
-
0.1% of the activity with lactose
-
-
?
phlorizin
phloretin + D-glucose
-
37°C, 2h
-
-
?
phlorizin + H2O
?
-
reaction is inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
phlorizin + H2O
phloretin + D-glucose
quercetin-3-glucoside + H2O
quercetin + D-glucose
-
reaction is marginally inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
quercetin-4'-glucoside + H2O
quercetin + D-glucose
-
reaction is marginally inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
salicin + H2O
?
-
1.6% of the activity with lactose
-
-
?
additional information
?
-
5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside + H2O
?
-
37°C, 1 h
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside + H2O
?
-
37°C, 1 hour, only cytosolic form of mature lactase
-
-
?
baohuoside I + H2O
? + D-glucose
-
-
-
-
?
baohuoside I + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
cellobiose + H2O
2 beta-D-glucose
-
14% of the activity with lactose
-
-
?
cellobiose + H2O
2 beta-D-glucose
-
16% of the activity with lactose
-
-
?
cellobiose + H2O
2 beta-D-glucose
-
25% of the activity with lactose
-
-
?
cellotetraose + 3 H2O
4 beta-D-glucose
-
9% of the activity with lactose
-
-
?
cellotetraose + 3 H2O
4 beta-D-glucose
-
14% of the activity with lactose
-
-
?
cellotriose + H2O
3 D-glucose
-
14% of the activity with lactose
-
-
?
cellotriose + H2O
3 D-glucose
-
9% of the activity with lactose
-
-
?
cellulose + H2O
beta-D-glucose
-
-
-
-
?
cellulose + H2O
beta-D-glucose
-
0.1% of the activity with lactose
-
-
?
cellulose + H2O
beta-D-glucose
-
0.1% of the activity with lactose
-
-
?
daidzein 7-O-beta-D-glucopyranoside + H2O
daidzein + beta-D-glucose
-
-
-
-
?
daidzein 7-O-beta-D-glucopyranoside + H2O
daidzein + beta-D-glucose
-
-
-
-
?
epimedin A + H2O
? + D-glucose
-
-
-
-
?
epimedin A + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
epimedin B + H2O
? + D-glucose
-
-
-
-
?
epimedin B + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
epimedin C + H2O
? + D-glucose
-
-
-
-
?
epimedin C + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
icariin + H2O
? + D-glucose
-
-
-
-
?
icariin + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
lactose + H2O
D-galactose + D-glucose
-
-
-
-
?
lactose + H2O
D-galactose + D-glucose
-
the nuclear transcription factor Oct-1 binds to the T variant at position -13910 upstream of the lactase gene and enhances transcription of the lactase gene
-
-
?
lactose + H2O
D-galactose + D-glucose
-
37°C, 2h
-
-
?
lactose + H2O
D-galactose + D-glucose
-
-
-
-
?
lactose + H2O
D-galactose + D-glucose
-
-
-
-
?
lactose + H2O
D-galactose + D-glucose
-
-
-
-
?
lactose + H2O
D-galactose + D-glucose
-
in rats grown under iron deficiency lactase-phlorizin hydrolase activity was 56.8% lower compared to control rats
-
-
?
lactose + H2O
D-galactose + D-glucose
-
1h, 37°C, pH 6.0
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
rotavirus RRV infection affects the lactose metabolism of enterocytes in the intestine, overview
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
most active substrate
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
lactose + H2O
D-glucose + D-galactose
-
-
-
?
o-nitrophenyl-beta-galactoside + H2O
o-nitrophenol + beta-D-galactose
-
17% of the activity with lactose
-
-
?
o-nitrophenyl-beta-galactoside + H2O
o-nitrophenol + beta-D-galactose
-
15.4% of the activity with lactose
-
-
?
p-nitrophenyl-beta-galactoside + H2O
p-nitrophenol + beta-D-galactose
-
13% of the activity with lactose
-
-
?
p-nitrophenyl-beta-galactoside + H2O
p-nitrophenol + beta-D-galactose
-
9.3% of the activity with lactose
-
-
?
p-nitrophenyl-beta-glucoside + H2O
p-nitrophenol + beta-D-glucose
-
10% of the activity with lactose
-
-
?
p-nitrophenyl-beta-glucoside + H2O
p-nitrophenol + beta-D-glucose
-
12.7% of the activity with lactose
-
-
?
phlorizin + H2O
phloretin + D-glucose
-
-
-
-
?
phlorizin + H2O
phloretin + D-glucose
-
22% of the activity with lactose
-
-
?
phlorizin + H2O
phloretin + D-glucose
-
at 2.3% of the activity with lactose
-
-
?
phlorizin + H2O
phloretin + D-glucose
-
-
-
?
additional information
?
-
-
no substrate: rutin, naringin
-
-
?
additional information
?
-
-
total lactase activity increases to reach maximal levels around weaning, and remains high subsequently, enzyme activity appears to be regulated during development predominantly by transcription mechanism, while alterations during lactation, and along the proximal to distal gradient, are the result of other control mechanism
-
-
?
additional information
?
-
-
absorption of quercetin-3-glucoside requires hydrolysis by the enzyme, absorption of quercetin-4-glucoside requires both an interaction with sodium-dependent glucose transporter and hydrolysis by the enzyme
-
-
?
additional information
?
-
-
enzyme plays a major role in metabolism of glycosylated phytochemicals
-
-
?
additional information
?
-
-
the enzyme has two distinct catalytic active sites, one for the hydrolysis of lactose and flavonoid glucosides and another, phlorizin hydrolase, for the hydrolysis of phlorizin and glucosylceramides
-
-
?
additional information
?
-
-
activity by the isolated intestinal enzyme on flavonoid glucosides in descending order: icariin, epimedin A, epimedin C, epimedin B, amd baohuoside I, mass spectrometric product analysis, detailed overview
-
-
?
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0.00164
-
non-infected cells, lactase enzyme activity in cell homogenates
0.00167
-
rhesus monkey rotavirus-, RRV, infected cells, lactase enzyme activity in cell homogenates
0.002
-
mutant S218fsX224, mean lactase activity
0.0021
-
mutant Y1390X, mean lactase activity
0.00219
-
rhesus monkey rotavirus-, RRV, infected cells, lactase enzyme activity in brush border-enriched fraction
0.003
-
mutant G1363S, mean lactase activity
0.0033
-
rats are force-fed a low-strach diet, with thyroid hormone treatment
0.00344
-
non-infected cells, lactase enzyme activity in brush border-enriched fraction
0.00359
-
UV, psoralen-inactivated RRV infected cells, lactase enzyme activity in brush border-enriched fraction
0.0042
-
rats are fed a low-starch diet for 7 days
0.0058
-
rats are force-fed a sucrose diet, with thyroid hormone treatment
0.0067
-
rats are fed a low-starch diet, starved for 3 days, and thyroid hormones are injected daily after the diet
0.01
-
rats are fed a high-starch diet for 7 days
0.012
-
rats are fed a low-starch diet, starved for 3 days
0.17
-
administration of thyroxine to 8-day-old pups, activity in suckling rat intestine
0.29
-
administration of insuline to 8-day-old pups, activity in suckling rat intestine
0.36
-
administration of cortisone to 8-day-old pups, activity in suckling rat intestine
450
-
phlorizin hydrolase
0.005
-
mutant Q268H, mean lactase activity
0.005
-
mutant S1666fsX1722, mean lactase activity
0.0083
-
rats are force-fed a low-strach diet, without thyroid hormone treatment
0.0083
-
rats are force-fed a sucrose diet, without thyroid hormone treatment
additional information
-
20% enzyme activity of mutant G1363S after incubation at 20°C for 22h
additional information
-
enzymatic activity of mutant G1363S below detection line
additional information
-
1.46 U/g intestinal tissue, soluble lactase, after treatment of rats with cortisone
additional information
-
10.96 U/g intestinal tissue, membrane bound lactase, after treatment of rats with cortisone
additional information
-
12.31 U/g intestinal tissue, homogenate, after treatment of rats with cortisone
additional information
-
2.37 U/g intestinal tissue, soluble lactase
additional information
-
2.44 U/g intestinal tissue, soluble lactase, after treatment of rats with thyroxine
additional information
-
4.82 U/g intestinal tissue, membrane bound lactase, after treatment of rats with thyroxine
additional information
-
7.10 U/g intestinal tissue, homogenate, after treatment of rats with thyroxine
additional information
-
7.38 U/g intestinal tissue, membrane bound lactase
additional information
-
9.83 U/g intestinal tissue, homogenate
additional information
analysis of lactase phlorizin hydrolase activity in germfree, Lactobacillus fermentum or Escherichia coli monoassociated, Klebsiella pneumoniae LF diassociated and conventional pigs (measuring the amount of D-glucose liberated from lactose). Lowest lactase phlorizin hydrolase activity is observed in pigs, monoassociated with Lactobacillus fermentum. Lactase phlorizin hydrolase activity to mRNA ratio is reduced in enterocytes of pigs monoassociated with Lactobacillus fermentum as compared with germfree pigs
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D1711N
-
introduction of potential N-glycosilation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency
E1612X
results in congenital lactase deficiency
I1697N
-
introduction of potential N-glycosilation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency
more |
-
CC13910, lactose intolerance, low lactase genotype, no predispose for cataracts with mutation of galactose-1-phosphate uridyl transferase
P1743S
-
introduction of potential N-glycosilation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency
Q268H
-
congential lactase deficiency, CLD, mutation, DNA mutation c.804G->C, genotype compound heterozygote for Y1390X
R1587H
results in congenital lactase deficiency
S1666fsX1722
-
congential lactase deficiency, CLD, mutation, DNA mutation c.4998_5001delTGAG, genotype compound heterozygote for Y1390X
S218fsX224
-
congential lactase deficiency, CLD, mutation, DNA mutation c.653_654delCT, genotype compound heterozygote for Y1390X
S688P
results in congenital lactase deficiency
up
thyroid and glucocorticoid hormones synergistically enhance expression of the LPH gene in CDX-2/HNF-1alphaa co-transfected IEC-6 cells
G1363S
-
congential lactase deficiency, CLD, mutation, DNA mutation c.4087G->A, genotype compound heterozygote for Y1390X
G1363S
-
misfolded, rest in endoplasmatic reticulum, congenital lactase deficiency, temperature sensitive
G1363S
results in congenital lactase deficiency
Y1390X
-
congential lactase deficiency, CLD, mutation, DNA mutation c.4170T->A, genotype homozygote
Y1390X
results in congenital lactase deficiency
additional information
-
C/C-13910, less enzyme activity, lactase non-persistence, adult type hypolactasia
additional information
-
C/T-13910, less enzyme activity, lactase persistence
additional information
-
CT13910, high lactase genotype
additional information
-
T/T-13910, less enzyme activity, lactase persistence
additional information
-
TT13910, high lactase genotype
additional information
the enzyme without domain II (LPHDELTA2) is normally transported along the secretory pathway, but does not dimerize nor is enzymatically active
additional information
removal of domain I (LPHDELTA1) results in a malfolded ER-localized protein. Enzyme without domain II (LPHDELTA2) is normally transported along the secretory pathway, but does not dimerize nor is enzymatically active. The lactase activity is not detectable in LPHDELTA1 and LPHDELTA2. Phlorizin hydrolase activity is only detectable in LPHDELTA2, albeit at substantially reduced levels of 4.3%
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Day, A.J.; Canada, F.J.; Diaz, J.C.; Kroon, P.A.; Mclauchlan, R.; Faulds, C.B.; Plumb, G.W.; Morgan, M.R.A.; Williamson, G.
Dietary flavonoids and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
FEBS Lett.
468
166-170
2000
Ovis aries
brenda
Jacob, R.; Weiner, J.R.; Stadge, S.; Naim, H.Y.
Additional N-glycosylation and its impact on the folding of intestinal lactase-phlorizin hydrolase
J. Biol. Chem.
275
10630-10637
2000
Homo sapiens
brenda
Skovbjerg, H.; Sjstrm, H.; Noren, O.
Purification and characterization of amphiphilic lactase/phlorizin hydrolase from human small intestine
Eur. J. Biochem.
114
653-661
1981
Homo sapiens
brenda
Skovbjerg, H.; Noren, O.; Sjstrm, H.; Danielsen, E.M.; Enevoldsen, B.S.
Further characterization of intestinal lactase/phlorizin hydrolase
Biochim. Biophys. Acta
707
89-97
1982
Homo sapiens, Sus scrofa
brenda
Ramaswamy, S.; Radhakrishnan, A.N.
Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites
Biochim. Biophys. Acta
403
446-455
1975
Platyrrhini
brenda
Schlegel-Haueter, S.; Hore, P.; Kerry, K.R.; Semenza, G.
The preparation of lactase and glucoamylase of rat small intestine
Biochim. Biophys. Acta
258
506-519
1972
Homo sapiens, Rattus norvegicus
brenda
Bueller, H.A.; Kothe, M.J.C.; Goldman, D.A.; Grubman, S.A.; Sasak, W.V.; Matsudaira, P.T.; Montgomery, R.K.; Grand, R.J.
Coordinate expression of lactate-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development
J. Biol. Chem.
265
6978-6953
1990
Rattus norvegicus
brenda
Day, A.J.; Gee, J.M.; DuPont, M.S.; Johnson, I.T.; Williamson, G.
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
Biochem. Pharmacol.
65
1199-1206
2003
Rattus norvegicus
brenda
Jacob, R.; Peters, K.; Naim, H.Y.
Prosequence of human lactase-phlorizin hydrolase modulates the folding of mature enzyme
J. Biol. Chem.
277
8217-8225
2002
Homo sapiens
brenda
Burrin, D.G.; Stoll, B.; Fan, M.Z.; Dudley, M.A.; Donovan, S.M.; Reeds, P.J.
Oral IGF-I alters the posttranslational processing but not the activity of lactase-phlorizin hydrolase in formula-fed neonatal pigs
J. Nutr.
131
2235-2241
2001
Sus scrofa
brenda
Wilkinson, A.P.; Gee, J.M.; Dupont, M.S.; Needs, P.W.; Mellon, F.A.; Williamson, G.; Johnson, I.T.
Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro
Xenobiotica
33
255-264
2003
Rattus norvegicus
brenda
West, A.R.; Oates, P.S.
Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1
Am. J. Physiol. Gastronintest. Liver Physiol.
289
G1108-G1114
2005
Rattus norvegicus
brenda
Hermida, C.; Corrales, G.; Martinez-Costa, O.H.; Fernandez-Mayoralas, A.; Aragon, J.J.
Noninvasive evaluation of intestinal lactase with 4-galactosylxylose: comparison with 3- and 2-galactosylxylose and optimization of the method in rats
Clin. Chem.
52
270-277
2006
Rattus norvegicus
brenda
Lewinsky, R.H.; Jensen, T.G.; M?ller, J.; Stensballe, A.; Olsen, J.; Troelsen, J.T.
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro
Hum. Mol. Genet.
14
3945-3953
2005
Homo sapiens
brenda
Kuranuki, S.; Mochizuki, K.; Goda, T.
Dietary sucrose enhances intestinal lactase gene expression in euthyroid rats
J. Nutr. Sci. Vitaminol.
52
347-351
2006
Rattus norvegicus
brenda
Beau, I.; Cotte-Laffitte, J.; Geniteau-Legendre, M.; Estes, M.K.; Servin, A.L.
An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells
Cell. Microbiol.
9
2254-2266
2007
Homo sapiens
brenda
Kuokkanen, M.; Kokkonen, J.; Enattah, N.S.; Ylisaukko-Oja, T.; Komu, H.; Varilo, T.; Peltonen, L.; Savilahti, E.; Jarvela, I.
Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency
Am. J. Hum. Genet.
78
339-344
2006
Homo sapiens
brenda
He, W.; Ji, Z.Y.; Huang, C.Y.
Molecular cloning of a novel cDNA from Mus muscular BALB/c mice encoding glycosyl hydrolase family 1: a homolog of human lactase-phlorizin hydrolase
Biomed. Environ. Sci.
19
340-345
2006
Mus musculus, Mus musculus BALB/c
brenda
Hermida, C.; Corrales, G.; Canada, F.J.; Aragon, J.J.; Fernandez-Mayoralas, A.
Optimizing the enzymatic synthesis of beta-D-galactopyranosyl-D-xyloses for their use in the evaluation of lactase activity in vivo
Bioorg. Med. Chem.
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Rattus norvegicus
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Bernardes-Silva Carlos Felip, B.C.; Pereira Alexandre , P.A.; de Fatima Alves da Mota Glori, d.F.; Krieger Jose Eduard, K.J.; Laudanna Antonio Atili, L.A.
Lactase persistence/non-persistence variants, C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients
Clin. Chim. Acta
386
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2007
Homo sapiens
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Tamura, A.; Shiomi, T.; Hachiya, S.; Shigematsu, N.; Hara, H.
Low activities of intestinal lactase suppress the early phase absorption of soy isoflavones in Japanese adults
Clin. Nutr.
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2008
Homo sapiens
brenda
Imtiaz , I.F.; Savilahti , S.E.; Sarnesto , S.A.; Trabzuni , T.D.; Al-Kahtani , A.K.; Kagevi , K.I.; Rashed M. , R.M.; Meyer B. , M.B.; Jarvela , J.I.
The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population
J. Med. Genet.
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2007
Homo sapiens
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Chaudhry, K.K.; Mahmood, S.; Mahmood, A.
Hormone induced expression of brush border lactase in suckling rat intestine
Mol. Cell. Biochem.
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Rattus norvegicus
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Torniainen, S.; Freddara, R.; Routi, T.; Gijsbers, C.; Catassi, C.; Hoeglund, P.; Savilahti, E.; Jaervelae, I.
Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD)
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Homo sapiens (P09848), Homo sapiens
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Karas-Kuzelicki, N.; Pfeifer, V.; Lukac-Bajalo, J.
Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation
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2008
Homo sapiens
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Behrendt, M.; Keiser, M.; Hoch, M.; Naim, H.Y.
Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency
Gastroenterology
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2009
Homo sapiens
brenda
Fabre, J.W.; Salehi, S.; Eckley, L.; Sawyer, G.J.; Zhang, X.; Dong, X.; Freund, J.N.
Intestinal lactase as an autologous beta-galactosidase reporter gene for in vivo gene expression studies
Hum. Gene Ther.
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Escherichia coli, Rattus norvegicus
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Willing, B.P.; Van Kessel, A.G.
Intestinal microbiota differentially affect brush border enzyme activity and gene expression in the neonatal gnotobiotic pig
J. Anim. Physiol. Anim. Nutr. (Berl.)
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2008
Sus scrofa (Q29587)
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Tanaka, T.; Suzuki, A.; Kuranuki, S.; Mochizuki, K.; Suruga, K.; Takase, S.; Goda, T.
Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions
Life Sci.
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Rattus norvegicus
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Chaudhry, K.K.; Mahmood, S.; Mahmood, A.
Hormone induced changes in lactase glycosylation in developing rat intestine
Mol. Cell. Biochem.
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2008
Rattus norvegicus
brenda
Khabarova, Y.A.; Torniainen, S.T.; Nurmi, H.A.; Jaervelae, I.E.; Isokoski, M.K.; Mattila, K.J.
Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia
World J. Gastroenterol.
15
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2009
Homo sapiens
brenda
Koek, W.; van Meurs, J.; van der Eerden, B.; Rivadeneira, F.; Zillikens, M.; Hofman, A.; Obermayer-Pietsch, B.; Lips, P.; Pols, H.; Uitterlinden, A.; van Leeuwen, J.
The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
J. Bone Miner. Res.
25
1980-1987
2010
Homo sapiens
brenda
Ingram, C.J.; Raga, T.O.; Tarekegn, A.; Browning, S.L.; Elamin, M.F.; Bekele, E.; Thomas, M.G.; Weale, M.E.; Bradman, N.; Swallow, D.M.
Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
J. Mol. Evol.
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2009
Homo sapiens
brenda
Khabarova, Y.; Torniainen, S.; Savilahti, E.; Isokoski, M.; Mattila, K.; Jaervelae, I.
The -13914G>A variant upstream of the lactase gene (LCT) is associated with lactase persistence/non-persistence
Scand. J. Clin. Lab. Invest.
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354-357
2010
Homo sapiens
brenda
Kuchay, R.A.; Thapa, B.R.; Mahmood, A.; Mahmood, S.
Effect of C/T -13910 cis-acting regulatory variant on expression and activity of lactase in Indian children and its implication for early genetic screening of adult-type hypolactasia
Clin. Chim. Acta
412
1924-1930
2011
Homo sapiens
brenda
Naz, S.; Siddiqi, R.; Dew, T.P.; Williamson, G.
Epigallocatechin-3-gallate inhibits lactase but is alleviated by salivary proline-rich proteins
J. Agric. Food Chem.
59
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2011
Rattus norvegicus
brenda
Zhou, J.; Chen, Y.; Wang, Y.; Gao, X.; Qu, D.; Liu, C.
A comparative study on the metabolism of Epimedium koreanum nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora
Molecules
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177-203
2014
Rattus norvegicus
brenda
Zou, S.; He, X.; Liu, Y.; Chen, D.; Luo, Y.; Huang, K.; Zhang, W.; Xu, W.
Toxicological evaluation of lactase derived from recombinant Pichia pastoris
PLoS ONE
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e106470
2014
Aspergillus oryzae
brenda
Diekmann, L.; Behrendt, M.; Amiri, M.; Naim, H.Y.
Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein
Biochim. Biophys. Acta
1861
3119-3128
2017
Homo sapiens (P09848)
brenda
Suzuki, T.; Mochizuki, K.; Goda, T.
Thyroid and glucocorticoid hormones induce expression of lactase-phlorizin hydrolase gene in CDX-2/HNF-1alpha co-transfected IEC-6 cells
J. Nutr. Sci. Vitaminol.
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2015
Rattus norvegicus (Q02401)
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Diekmann, L.; Behrendt, M.; Amiri, M.; Naim, H.Y.
Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein
Biochim. Biophys. Acta Gen. Subj.
1861
3119-3128
2017
Homo sapiens (P09848)
brenda