3.2.1.108: lactase
This is an abbreviated version!
For detailed information about lactase, go to the full flat file.
Word Map on EC 3.2.1.108
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3.2.1.108
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sucrase
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milk
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maltase
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intolerance
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disaccharidase
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brush
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border
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mucosal
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jejunal
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gastrointestinal
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malabsorption
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breath
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children
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dairy
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wean
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villus
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diarrhea
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enterocytes
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infant
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bowel
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ileum
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hypolactasia
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suckling
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crypt
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duodenal
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aminopeptidase
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piglets
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trehalase
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brush-border
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non-persistence
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sucrase-isomaltase
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maldigestion
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adult-type
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yogurt
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glucoamylase
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3.2.1.23
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isomaltase
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lactulose
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bloating
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small-intestinal
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microvillus
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coeliac
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flatulence
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archaeological
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maltase-glucoamylase
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medicine
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crypt-villus
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pharmacology
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food industry
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cellobiase
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carbohydrases
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formula-fed
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pastor
- 3.2.1.108
- sucrase
- milk
- maltase
- intolerance
- disaccharidase
-
brush
- border
- mucosal
- jejunal
- gastrointestinal
- malabsorption
- breath
- children
-
dairy
-
wean
- villus
-
diarrhea
- enterocytes
- infant
- bowel
- ileum
- hypolactasia
-
suckling
-
crypt
- duodenal
- aminopeptidase
-
piglets
- trehalase
-
brush-border
-
non-persistence
- sucrase-isomaltase
-
maldigestion
-
adult-type
-
yogurt
- glucoamylase
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3.2.1.23
- isomaltase
- lactulose
-
bloating
-
small-intestinal
- microvillus
-
coeliac
-
flatulence
-
archaeological
- maltase-glucoamylase
- medicine
-
crypt-villus
- pharmacology
- food industry
- cellobiase
-
carbohydrases
-
formula-fed
-
pastor
Reaction
Synonyms
intestinal lactase, lactase, lactase phlorizin hydrolase, lactase phlorizin-hydrolase, lactase-phlorizin hydrolase, lactase-phlorizin hydrolase LPH, lactase-phlorozin hydrolase, lactase/phlorizin hydrolase, LCT, LPH
ECTree
3.2.1.108 lactaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.2.1.108 - lactase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-O-beta-D-galactopyranosyl-D-xylose + H2O
D-galactose + D-xylose
-
-
-
-
?
3-O-beta-D-galactopyranosyl-D-xylose + H2O
D-galactose + D-xylose
-
-
-
-
?
4-O-beta-D-galactopyranosyl-D-xylose + H2O
D-galactose + D-xylose
-
-
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-fucopyranoside + H2O
?
-
37°C, 1 hour, full-length lactase, mature lactase, cytosolic form of mature lactase
-
-
?
fluorescein-di-beta-D-galactopyranoside + H2O
?
-
only cytosolic form of mature lactase
-
-
?
lactose + H2O
galactose + D-glucose
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reaction is not inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
methyl-beta-D-glucoside + H2O
methanol + beta-D-glucose
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7.3% of the activity with lactose
-
-
?
o-nitrophenyl-beta-glucoside + H2O
o-nitrophenol + beta-D-glucose
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13% of the activity with lactose
-
-
?
phenyl-beta-galactoside + H2O
phenol + beta-D-galactose
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0.1% of the activity with lactose
-
-
?
phlorizin + H2O
?
-
reaction is inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
quercetin-3-glucoside + H2O
quercetin + D-glucose
-
reaction is marginally inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
quercetin-4'-glucoside + H2O
quercetin + D-glucose
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reaction is marginally inhibited by 2-fluoro-dinotrophenylglucoside
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside + H2O
?
-
37°C, 1 h
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside + H2O
?
-
37°C, 1 hour, only cytosolic form of mature lactase
-
-
?
baohuoside I + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
cellobiose + H2O
2 beta-D-glucose
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14% of the activity with lactose
-
-
?
daidzein 7-O-beta-D-glucopyranoside + H2O
daidzein + beta-D-glucose
-
-
-
-
?
epimedin A + H2O
? + D-glucose
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from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
epimedin B + H2O
? + D-glucose
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from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
epimedin C + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
icariin + H2O
? + D-glucose
-
from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract
-
-
?
lactose + H2O
D-galactose + D-glucose
-
-
-
-
?
lactose + H2O
D-galactose + D-glucose
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the nuclear transcription factor Oct-1 binds to the T variant at position -13910 upstream of the lactase gene and enhances transcription of the lactase gene
-
-
?
lactose + H2O
D-galactose + D-glucose
-
-
-
-
?
lactose + H2O
D-galactose + D-glucose
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in rats grown under iron deficiency lactase-phlorizin hydrolase activity was 56.8% lower compared to control rats
-
-
?
lactose + H2O
D-glucose + D-galactose
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rotavirus RRV infection affects the lactose metabolism of enterocytes in the intestine, overview
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-
?
o-nitrophenyl-beta-galactoside + H2O
o-nitrophenol + beta-D-galactose
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17% of the activity with lactose
-
-
?
o-nitrophenyl-beta-galactoside + H2O
o-nitrophenol + beta-D-galactose
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15.4% of the activity with lactose
-
-
?
p-nitrophenyl-beta-galactoside + H2O
p-nitrophenol + beta-D-galactose
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13% of the activity with lactose
-
-
?
p-nitrophenyl-beta-galactoside + H2O
p-nitrophenol + beta-D-galactose
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9.3% of the activity with lactose
-
-
?
p-nitrophenyl-beta-glucoside + H2O
p-nitrophenol + beta-D-glucose
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10% of the activity with lactose
-
-
?
p-nitrophenyl-beta-glucoside + H2O
p-nitrophenol + beta-D-glucose
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12.7% of the activity with lactose
-
-
?
phlorizin + H2O
phloretin + D-glucose
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at 2.3% of the activity with lactose
-
-
?
additional information
?
-
-
total lactase activity increases to reach maximal levels around weaning, and remains high subsequently, enzyme activity appears to be regulated during development predominantly by transcription mechanism, while alterations during lactation, and along the proximal to distal gradient, are the result of other control mechanism
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-
?
additional information
?
-
-
absorption of quercetin-3-glucoside requires hydrolysis by the enzyme, absorption of quercetin-4-glucoside requires both an interaction with sodium-dependent glucose transporter and hydrolysis by the enzyme
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-
?
additional information
?
-
-
enzyme plays a major role in metabolism of glycosylated phytochemicals
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-
?
additional information
?
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-
the enzyme has two distinct catalytic active sites, one for the hydrolysis of lactose and flavonoid glucosides and another, phlorizin hydrolase, for the hydrolysis of phlorizin and glucosylceramides
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-
?
additional information
?
-
-
activity by the isolated intestinal enzyme on flavonoid glucosides in descending order: icariin, epimedin A, epimedin C, epimedin B, amd baohuoside I, mass spectrometric product analysis, detailed overview
-
-
?
