3.1.7.5: geranylgeranyl diphosphate diphosphatase

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For detailed information about geranylgeranyl diphosphate diphosphatase, go to the full flat file.

Reaction

Synonyms

geranylgeranyl diphosphate phosphatase, GGPP phosphatase, PDP, prenyl diphosphate phosphatase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.7 Diphosphoric-monoester hydrolases

                3.1.7.5 geranylgeranyl diphosphate diphosphatase

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Results	in table
1	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
8	Inhibitors
2	KM Value [mM]
3	Localization
2	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
3	Organism
3	Pathway
2	pH Optimum
2	pH Range
1	Protein Variants
1	Purification (Commentary)
1	Reaction
3	Reference
3	Source Tissue
2	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
2	Subunits
4	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 3.1.7.5 - geranylgeranyl diphosphate diphosphatase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Co2+

Croton stellatopilosus

-

1.0 mM, complete inhibition of isoenzyme PII, 21% inhibition of isoenzyme PI

694599

geranylgeranyl diphosphate

Croton stellatopilosus

-

substrate inhibition above 0.2 mM, isoenzyme PII. Isoenzyme PI shows no substrate inhibition

694599

K+

Croton stellatopilosus

-

1.0 mM, 18% inhibition of isoenzyme PI, slight activation (1.1fold) of isoenzyme PII

694599

Mn2+

Croton stellatopilosus

-

1.0 mM, complete inhibition of isoenzyme PII, 4% inhibition of isoenzyme PI

694599

Na+

Croton stellatopilosus

-

1.0 mM, 23% inhibition of isoenzyme PI, 5% inhibition of isoenzyme PII

694599

Na2MoO4

Croton stellatopilosus

-

1.0 mM, complete inhibition of isoenzyme PI and isoenzyme PII

694599

Zn2+

Croton stellatopilosus

-

1.0 mM, complete inhibition of isoenzyme PII, no inhibition of isoenzyme PI

694599

additional information

Croton stellatopilosus

-

isoenzyme PI shows no substrate inhibition by geranylgeranyl diphosphate, no inhibition by 1.0 mM Zn2+ or K+ and very low inhibition by 1 mM Na+

694599

-