3.1.7.5: geranylgeranyl diphosphate diphosphatase
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For detailed information about geranylgeranyl diphosphate diphosphatase, go to the full flat file.
Reaction
Synonyms
geranylgeranyl diphosphate phosphatase, GGPP phosphatase, PDP, prenyl diphosphate phosphatase
ECTree
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Engineering
Engineering on EC 3.1.7.5 - geranylgeranyl diphosphate diphosphatase
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additional information
construction of a series of N-terminal deletion mutants based on the locations of the transmembrane regionsand phosphatase motifs. The absence of the first transmembrane region yields a higher expression level than does the full-length cDNA construct, whereas the absence of the first two transmembrane regions prevents expression of the gene construct. The level of activity depends on the length of the expressed protein products. The absence of the first transmembrane region and part of the cytosolic region decreases the phosphatase activity by approximately 40%. The complete absence of both the first transmembrane and cytosolic regions causes a considerable decrease in enzymatic activity
additional information
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construction of a series of N-terminal deletion mutants based on the locations of the transmembrane regionsand phosphatase motifs. The absence of the first transmembrane region yields a higher expression level than does the full-length cDNA construct, whereas the absence of the first two transmembrane regions prevents expression of the gene construct. The level of activity depends on the length of the expressed protein products. The absence of the first transmembrane region and part of the cytosolic region decreases the phosphatase activity by approximately 40%. The complete absence of both the first transmembrane and cytosolic regions causes a considerable decrease in enzymatic activity