3.1.6.19: (R)-specific secondary-alkylsulfatase (type III)

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For detailed information about (R)-specific secondary-alkylsulfatase (type III), go to the full flat file.

Reaction

Synonyms

(R)-specific sec-alkylsulfatase, Pisa1, S3 secondary alkylsulphohydrolase, sec-alkylsulfatase, sulfatase RS2

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.19 (R)-specific secondary-alkylsulfatase (type III)

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Results	in table
1	AA Sequence
4	Application
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
3	Inhibitors
8	kcat/KM [mM/s]
2	Ki Value [mM]
10	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
81	Organism
2	Pathway
7	pH Optimum
2	pH Range
1	pI Value
9	Protein Variants
2	Purification (Commentary)
1	Reaction
17	Reference
2	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Turnover Number [1/s]

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General Information on EC 3.1.6.19 - (R)-specific secondary-alkylsulfatase (type III)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Pseudomonas sp. DSM 6611

F8KAY7

Pisa1 shows a preference for secondary rather than primary alkyl sulfates, and enantioselectively hydrolyzes the (R)-enantiomer of rac-2-octyl sulfate, yielding (S)-2-octanol with inversion of absolute configuration as a result of C-O bond cleavage. An invariant histidine (His317) near the sulfate-binding site acts as general acid for crucial protonation of the sulfate leaving group

761062