3.1.6.19: (R)-specific secondary-alkylsulfatase (type III)

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For detailed information about (R)-specific secondary-alkylsulfatase (type III), go to the full flat file.

Reaction

Synonyms

(R)-specific sec-alkylsulfatase, Pisa1, S3 secondary alkylsulphohydrolase, sec-alkylsulfatase, sulfatase RS2

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.19 (R)-specific secondary-alkylsulfatase (type III)

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1	AA Sequence
4	Application
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
3	Inhibitors
8	kcat/KM [mM/s]
2	Ki Value [mM]
10	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
81	Organism
2	Pathway
7	pH Optimum
2	pH Range
1	pI Value
9	Protein Variants
2	Purification (Commentary)
1	Reaction
17	Reference
2	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.1.6.19 - (R)-specific secondary-alkylsulfatase (type III)

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SYSTEMATIC NAME

IUBMB Comments

(R)-secondary-alkyl sulfate sulfohydrolase [(S)-secondary-alcohol-forming]

Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. The enzyme from the bacterium Rhodococcus ruber prefers linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates [1]. The enzyme from the bacterium Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties. Hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom, resulting in perfect enantioselectivity. cf. EC 3.1.6.1, arylsulfatase (type I), and EC 1.14.11.77, alkyl sulfatase (type II).