3.1.6.1: arylsulfatase (type I)

This is an abbreviated version!
For detailed information about arylsulfatase (type I), go to the full flat file.

Word Map on EC 3.1.6.1

3.1.6.1

lysosomal

metachromatic

leukodystrophy

beta-glucuronidase

steroid

urine

mucopolysaccharidosis

sulfatide

leukocyte

urinary

asa

estrone

glycosaminoglycans

glucuronide

demyelination

cerebroside

urease

sulfotransferase

aromatase

heparan

beta-glucosidase

desulfation

dehydroepiandrosterone

dermatan

infantile

17beta-hydroxysteroid

mucopolysaccharide

pomatia

ichthyosis

hexosaminidase

morquio

saposins

iduronate

17beta-hsds

galactosylceramide

alpha-fucosidase

chondrodysplasia

hspgs

synthesis

medicine

deconjugation

analysis

6-o-sulfate

tibolone

alpha-l-iduronidase

loam

sanfilippo

galns

punctata

mucolipidosis

sulfamate

4-sulfate

dysostosis

Reaction

Synonyms

4-methylumbelliferyl sulfatase, ARS, ARS-A, ARS-B, ARSA, ARSB, ARSE, ARSK, ary 423, Aryl-sulfate sulphohydrolase, arylsufatase B, arylsulfatase, arylsulfatase A, arylsulfatase B, arylsulfatase E, arylsulfatase Es-2, arylsulfatase G, arylsulfatase gene, arylsulfatase III, arylsulfatase J, arylsulfatase K, arylsulfatase type VI, arylsulfate sulfohydrolase II, arylsulfohydrolase, arylsulphatase, arylsulphatase A, AS-A, ASG, AstA, AtsA, estrogen sulfatase, KIAA1001, nitrocatechol sulfatase, p-nitrophenyl sulfatase, P70, PAS, phenolsulfatase, phenylsulfatase, sulfatase, sulfatase, aryl-

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.6 Sulfuric-ester hydrolases

3.1.6.1 arylsulfatase (type I)

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Results	in table
3	Activating Compound
11671	AA Sequence
18	Application
1	CAS Registry Number
20	Cloned(Commentary)
2	Crystallization (Commentary)
5001	Disease/ Diagnostics
12	Expression
6	General Information
1	General Stability
4	IC50 Value
201	Inhibitors
11	kcat/KM [mM/s]
7	Ki Value [mM]
104	KM Value [mM]
35	Localization
19	Metals/Ions
40	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
107	Organism
3	Pathway
19	PDB ID
50	pH Optimum
14	pH Range
10	pH Stability
11	Posttranslational Modification
19	Protein Variants
32	Purification (Commentary)
1	Reaction
1	Reaction Type
106	Reference
78	Source Tissue
41	Specific Activity [micromol/min/mg]
9	Storage Stability
207	Substrates and Products (Substrate)
18	Subunits
72	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
7	Temperature Range [°C]
18	Temperature Stability [°C]
30	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.1.6.1 - arylsulfatase (type I)

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aryl-sulfate sulfohydrolase

Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, formylglycine-generating enzyme, EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme.