3.1.6.1: arylsulfatase (type I)
This is an abbreviated version!
For detailed information about arylsulfatase (type I), go to the full flat file.
Word Map on EC 3.1.6.1
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3.1.6.1
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lysosomal
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metachromatic
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leukodystrophy
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beta-glucuronidase
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steroid
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urine
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mucopolysaccharidosis
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sulfatide
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leukocyte
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urinary
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asa
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estrone
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glycosaminoglycans
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glucuronide
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demyelination
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cerebroside
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urease
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sulfotransferase
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aromatase
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heparan
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beta-glucosidase
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desulfation
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dehydroepiandrosterone
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dermatan
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infantile
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17beta-hydroxysteroid
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mucopolysaccharide
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pomatia
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ichthyosis
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hexosaminidase
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morquio
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saposins
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iduronate
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17beta-hsds
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galactosylceramide
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alpha-fucosidase
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chondrodysplasia
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hspgs
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synthesis
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medicine
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deconjugation
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analysis
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6-o-sulfate
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tibolone
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alpha-l-iduronidase
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loam
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sanfilippo
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galns
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punctata
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mucolipidosis
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sulfamate
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4-sulfate
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dysostosis
- 3.1.6.1
- lysosomal
-
metachromatic
- leukodystrophy
- beta-glucuronidase
- steroid
- urine
- mucopolysaccharidosis
- sulfatide
- leukocyte
- urinary
- asa
- estrone
- glycosaminoglycans
-
glucuronide
- demyelination
- cerebroside
- urease
-
sulfotransferase
- aromatase
- heparan
- beta-glucosidase
-
desulfation
- dehydroepiandrosterone
- dermatan
-
infantile
-
17beta-hydroxysteroid
-
mucopolysaccharide
- pomatia
- ichthyosis
- hexosaminidase
- morquio
-
saposins
-
iduronate
- 17beta-hsds
- galactosylceramide
- alpha-fucosidase
-
chondrodysplasia
-
hspgs
- synthesis
- medicine
-
deconjugation
- analysis
-
6-o-sulfate
- tibolone
- alpha-l-iduronidase
-
loam
-
sanfilippo
- galns
- punctata
- mucolipidosis
- sulfamate
- 4-sulfate
- dysostosis
Reaction
Synonyms
4-methylumbelliferyl sulfatase, ARS, ARS-A, ARS-B, ARSA, ARSB, ARSE, ARSK, ary 423, Aryl-sulfate sulphohydrolase, arylsufatase B, arylsulfatase, arylsulfatase A, arylsulfatase B, arylsulfatase E, arylsulfatase Es-2, arylsulfatase G, arylsulfatase gene, arylsulfatase III, arylsulfatase J, arylsulfatase K, arylsulfatase type VI, arylsulfate sulfohydrolase II, arylsulfohydrolase, arylsulphatase, arylsulphatase A, AS-A, ASG, AstA, AtsA, estrogen sulfatase, KIAA1001, nitrocatechol sulfatase, p-nitrophenyl sulfatase, P70, PAS, phenolsulfatase, phenylsulfatase, sulfatase, sulfatase, aryl-
ECTree
3.1.6.1 arylsulfatase (type I)Advanced search results
results (
results (Inhibitors
Inhibitors on EC 3.1.6.1 - arylsulfatase (type I)
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
3-(alpha-acetonylbenzyl)-4-hydroxycoumarin
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2.5 mM results in 50% reduced activity of arylsulfatase
Al3+
1 mM, less than 20% residual activity, both free and immobilized enzyme
Fe2+
1 mM, less than 20% residual activity, both free and immobilized enzyme
guanidine hydrochloride
1 mM, 69.5% of initial activity, mutant H260L
IPTG
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at concentrations from 50 micromolar up to 5000 micromolar of IPTG the activity decreases by more than 50%
N-benzyloxycarbonyl-L-Phe-L-Tyr-O-sulfate methyl ester
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hydrolysis of 4-nitrophenyl sulfate
praziquantel
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schistosomical drug, inhibitory to enzyme. No effect on immunological properties of enzyme
Triton X-100
1 mM, 15% residual activity, free enzyme, 35% residual activity, immobilized enzyme, respectively
Tween 80
1 mM, 10% residual activity, free enzyme, 60% residual activity, immobilized enzyme, respectively
2-mercaptoethanol
1 mM, 70% residual activity, both free and immobilized enzyme
2-mercaptoethanol
1 mM, 81% of initial activity, mutant H260L
Ag+
1 mM, less than 20% residual activity, both free and immobilized enzyme
Cd2+
1 mM, less than 20% residual activity, both free and immobilized enzyme
Cu2+
1 mM, less than 20% residual activity, both free and immobilized enzyme
dithiothreitol
1 mM, 69.8% of initial activity, mutant H260L
EDTA
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0.1 mM EDTA 46.8% relative activity, 0.5 mM EDTA 39.6% relative activity and 1.0 mM EDTA 30.5% relative activity compared to the control
Fe3+
1 mM, less than 20% residual activity, both free and immobilized enzyme
phosphate
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acts as a strong, competitive ASG inhibitor, inhibition of ASG by phosphate is much stronger than by sulfate
PMSF
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0.1 mM PMSF 92.7% relative activity, 0.5 mM PMSF 82.6% relative activity and 1.0 mM PMSF 73.5% relative activity compared to the control
PMSF
1 mM, 15% residual activity, free enzyme, 35% residual activity, immobilized enzyme, respectively
SDS
1 mM, 5% residual activity, free enzyme, 45% residual activity, immobilized enzyme, respectively
Zn2+
1 mM, less than 20% residual activity, both free and immobilized enzyme
additional information
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SO42- and Ag+ ions have no effect on the enzyme activity
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additional information
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ASG is not inhibited by warfarin even at concentrations close to the solubility limit
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additional information
neither inhibitory nor activating: Ca2+, K+, Ba2+, Mg2+, Mn2+ and Sn2+
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