3.1.27.8: Ribonuclease V
This is an abbreviated version!
For detailed information about Ribonuclease V, go to the full flat file.
Word Map on EC 3.1.27.8
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3.1.27.8
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pyrimidine
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deaminate
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nick
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dimer-specific
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deoxyinosine
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phosphodiester
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cyclobutane
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repair-deficient
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inosine-containing
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abasic
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dimer-containing
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incises
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deoxyinosine-containing
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n-glycosylase
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cis-syn
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dna-interactive
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uracil-containing
- 3.1.27.8
- pyrimidine
-
deaminate
- nick
-
dimer-specific
- deoxyinosine
-
phosphodiester
-
cyclobutane
-
repair-deficient
-
inosine-containing
-
abasic
-
dimer-containing
-
incises
-
deoxyinosine-containing
-
n-glycosylase
-
cis-syn
-
dna-interactive
-
uracil-containing
Reaction
hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP =
Synonyms
endonuclease V, EndoV, FLJ35220, FLJ35220 protein, hEndoV
ECTree
3.1.27.8 Ribonuclease VAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.1.27.8 - Ribonuclease V
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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endonuclease Vs are inosine-specific nucleases that cleave at the second phosphodiester bond 3' to inosine. The human enzyme is most active towards ssRNA but is much less active towards other substrates
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additional information
?
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endonuclease Vs are inosine-specific nucleases that cleave at the second phosphodiester bond 3' to inosine. The human enzyme is most active towards ssRNA but is much less active towards other substrates
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?
additional information
?
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the human endonuclease V ribonuclease is specific for inosine-containing RNA, it preferentially binds to RNA and efficiently hydrolyses the second phosphodiester bond located 3' to the inosine in unpaired inosine-containing ssRNA regions in dsRNA, at 5'-IIUI-3' and 5'-UIUU-3'. But hEndoV can also cleave ssDNA substrates containing deoxyinosine. RNA is preferred to DNA by the enzyme as a substrate
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?
additional information
?
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the human endonuclease V ribonuclease is specific for inosine-containing RNA, it preferentially binds to RNA and efficiently hydrolyses the second phosphodiester bond located 3' to the inosine in unpaired inosine-containing ssRNA regions in dsRNA, at 5'-IIUI-3' and 5'-UIUU-3'. But hEndoV can also cleave ssDNA substrates containing deoxyinosine. RNA is preferred to DNA by the enzyme as a substrate
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