3.1.27.8: Ribonuclease V

This is an abbreviated version!
For detailed information about Ribonuclease V, go to the full flat file.

Word Map on EC 3.1.27.8

3.1.27.8

pyrimidine

deaminate

nick

dimer-specific

deoxyinosine

phosphodiester

cyclobutane

repair-deficient

inosine-containing

abasic

dimer-containing

incises

deoxyinosine-containing

n-glycosylase

cis-syn

dna-interactive

uracil-containing

Reaction

hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP =

Synonyms

endonuclease V, EndoV, FLJ35220, FLJ35220 protein, hEndoV

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.27 Endoribonucleases producing 3'-phosphomonoesters

3.1.27.8 Ribonuclease V

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Results	in table
1	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
2	General Information
1	KM Value [mM]
1	Localization
1	Metals/Ions
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organism
2	pH Optimum
8	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
7	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
2	Temperature Optimum [°C]

General Information

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General Information on EC 3.1.27.8 - Ribonuclease V

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evolution

Homo sapiens

Q8N8Q3

the enzyme preserves the general RNase H-like structure, especially in the wedge motif, the metal-binding site and the hypoxanthine-binding pocket. The human enzyme also features several extra insertions and a characteristic four cysteine motif, in which Cys227 and Cys228, two cysteines that are highly conserved in higher eukaryotes, play important roles in catalysis

728877

additional information

2 entries