3.1.13.B1: 5'-3' exoribonuclease
This is an abbreviated version!
For detailed information about 5'-3' exoribonuclease, go to the full flat file.
Word Map on EC 3.1.13.B1
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3.1.13.B1
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decapping
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sfrnas
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deadenylation
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flaviviruses
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exonucleolytic
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pyrophosphohydrolase
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exoribonucleolytic
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p-bodies
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pre-rrnas
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pacman
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flaviviral
- 3.1.13.B1
-
decapping
-
sfrnas
-
deadenylation
- flaviviruses
-
exonucleolytic
-
pyrophosphohydrolase
-
exoribonucleolytic
-
p-bodies
- pre-rrnas
-
pacman
-
flaviviral
Reaction
exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates =
Synonyms
5'-3' exoribonuclease 2, 5'-to-3' exoribonuclease, Pab-RNase J, PAB1751, Rat1, Saci-aCPSF2, Saci2362, Sso-RNase J, SSO0386, Tk-RNase J, Tk1469
ECTree
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Activating Compound
Activating Compound on EC 3.1.13.B1 - 5'-3' exoribonuclease
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ATP
ATP significantly enhances Rat1/Rai1-mediated RNAPII termination. The ATP-dependent effect seems to be unique to Rat1/Rai1. ATP addition does not stimulate the processivity of Rat1. Rather, it slightly reduces the exonuclease activity because 1 mM of ATP is sufficient to chelate the Mg2+ ion necessary for the nuclease activity of Rat1, suggesting that ATP affects Rat1-mediated termination in a somewhat different manner
NTP misincorporation induces RNAPII pausing and enhances termination by Rat1/Rai1. When ATP misincorporates into RNA transcripts, the elongation of RNAPII is significantly blocked, presumably due to the disruption and/or rearrangement of the RNAPII active center, RNAPII with a disrupted active center might be more effectively terminated by Rat1/Rai1
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additional information
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NTP misincorporation induces RNAPII pausing and enhances termination by Rat1/Rai1. When ATP misincorporates into RNA transcripts, the elongation of RNAPII is significantly blocked, presumably due to the disruption and/or rearrangement of the RNAPII active center, RNAPII with a disrupted active center might be more effectively terminated by Rat1/Rai1
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