3.1.11.7: adenosine-5'-diphospho-5'-[DNA] diphosphatase
This is an abbreviated version!
For detailed information about adenosine-5'-diphospho-5'-[DNA] diphosphatase, go to the full flat file.
Word Map on EC 3.1.11.7
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3.1.11.7
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apraxia
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oculomotor
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single-strand
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ocular
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cerebellar
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early-onset
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hypoalbuminemia
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polynucleotide
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5'-adenylated
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xrcc4
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friedreich
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ataxia-oculomotor
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fen1
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forkhead-associated
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deadenylation
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medicine
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cross-complementing
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3'-phosphoglycolate
- 3.1.11.7
- apraxia
-
oculomotor
-
single-strand
-
ocular
- cerebellar
-
early-onset
- hypoalbuminemia
- polynucleotide
-
5'-adenylated
- xrcc4
- friedreich
-
ataxia-oculomotor
- fen1
-
forkhead-associated
-
deadenylation
- medicine
-
cross-complementing
-
3'-phosphoglycolate
transferred to EC 3.6.1.71
Synonyms
Synonyms
aprataxin, APTX, DNA-adenylate hydrolase, HNT3, RNA-DNA deadenylase
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Natural Substrates Products
Natural Substrates Products on EC 3.1.11.7 - adenosine-5'-diphospho-5'-[DNA] diphosphatase
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REACTION DIAGRAM
adenosine-5'-diphospho-5'-[DNA] + H2O
AMP + phospho-5'-[DNA]
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aprataxin hydrolyses abnormal 5'-AMP DNA termini formed in abortive DNA ligations
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additional information
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APTX-mediated DNA deadenylation activity (i.e. 5'-AMP removal) is measured in extracts of cells expressing wild-type XRCC1 or the XRCC1 phosphorylation mutant, and compared with activity in APTX-deficient and APTX-complemented human cells. APTX activity is lower in extracts from Xrcc1-/- and XRCC1 phosphorylation mutant cells compared to the robust activity in extract from wild-type XRCC1 expressing cells. And APTX-mediated DNA deadenylation activity (i.e. 5'-AMP removal) is measured in cell extracts of the XRCC1 variants, and compared with activity in patient AOA1 human fibroblasts and APTX-complemented cells
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