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2.1.3.15: acetyl-CoA carboxytransferase

This is an abbreviated version!
For detailed information about acetyl-CoA carboxytransferase, go to the full flat file.

Word Map on EC 2.1.3.15

Reaction

[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine
+
acetyl-CoA
=
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine
+
malonyl-CoA

Synonyms

ACC, ACC2, accAD, ACCase, accD5, accD6, Acetyl CoA carboxylase, acetyl-CoA carboxylase, acetyl-CoA carboxylase carboxyltransferase domain, carboxyltransferase, CT-alphabeta subcomplex

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.15 acetyl-CoA carboxytransferase

Inhibitors

Inhibitors on EC 2.1.3.15 - acetyl-CoA carboxytransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3S)-beta-phenylalanine-L-valine-(4S)-methyl-2,5-pyrrolidinedione
-
-
(3S)-L-valine-(4S)-methyl-2,5-pyrrolidinedione
-
-
(3S)-methyl-2,5-pyrrolidinedione
-
-
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled soraphen A
-
-
malonyl-CoA
-
product inhibition
moiramide B
-
-
oleic acid
-
irreversible enzyme inhibition
palmitoyl-acyl carrier protein
-
allosteric, time-dependent, competitive inhibition
-
pantothenic acid
-
potent inhibitor
succinimide
-
-
Tween 80
-
reversible enzyme inhibition at 10 mM
additional information
-
incorporation of biotin attachment domain-containing proteins (inactive analogs of biotin carboxyl transfer proteins that lack biotin) into the enzyme down-regulates its activity by displacing active (biotin-containing) biotin carboxyltransferase protein subunits
-