2.1.1.35: tRNA (uracil54-C5)-methyltransferase

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For detailed information about tRNA (uracil54-C5)-methyltransferase, go to the full flat file.

Reaction

Synonyms

5-methyluridine 54 tRNA methyltransferase, m5U 54 tRNA methyltransferase, m5U 54 tRNA MTase, m5U methyltransferase, m5U-methyltransferase, methyltransferase, transfer ribonucleate uracil 5-, PAB0719, PAB0719 enzyme, PabTrmU54, ribothymidyl synthase, rTase, RumA, RumA-type tRNA(uracil-54, C5)-methyltransferase, RUMT, S-adenosyl-L-methionine-dependent tRNA (uracil-54, C5)-methyltransferase, transfer RNA uracil 5-methyltransferase, transfer RNA uracil methylase, TrmA, TRMT2A, tRNA (uracil-54, C5)-methyltransferase, tRNA uracil 5-methyltransferase, tRNA(m5U54)methyltransferase, tRNA(uracil-5-)methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.35 tRNA (uracil54-C5)-methyltransferase

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Results	in table
9	Activating Compound
8744	AA Sequence
3	Application
1	CAS Registry Number
12	Cloned(Commentary)
30	Cofactor
2	Crystallization (Commentary)
19	Disease/ Diagnostics
1	General Information
2	General Stability
42	Inhibitors
4	Ki Value [mM]
23	KM Value [mM]
9	Localization
12	Metals/Ions
13	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
102	Organism
2	PDB ID
10	pH Optimum
1	pH Range
13	Protein Variants
18	Purification (Commentary)
16	Reaction
3	Reaction Type
45	Reference
2	Source Tissue
8	Specific Activity [micromol/min/mg]
6	Storage Stability
152	Substrates and Products (Substrate)
12	Subunits
26	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

General Information

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General Information on EC 2.1.1.35 - tRNA (uracil54-C5)-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Homo sapiens

Q8IZ69

TRMT2A is responsible for the majority of m5U present in human RNA, it commonly targets U54 of cytosolic tRNAs. In both HAP-1 and HEK-293 TRMT2A knockout cell lines, the majority of m5U signal present in total RNA from control cell lines is absent

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